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Study: Medical Cannabis Treatment Associated with Sustained Relief, Decreased Use of Analgesics in Chronic Pain Patients

Haifa, Israel: Patients diagnosed with chronic pain experience sustained relief from the use of medical cannabis, and many of them reduce or eliminate their use of analgesic drugs over time, according to longitudinal data published in the European Journal of Pain.

A team of Israeli investigators evaluated the safety and efficacy of medical cannabis treatment over a one-year period in patients with chronic pain. Most subjects in the study consumed cannabis via smoking.

Following treatment, subjects’ average pain intensity declined from baseline by 20 percent. Nearly half of the subjects who had been using analgesic medications at the start of trial were no longer using them by the study’s end.

Authors reported: “Forty-three percent of the patients who had been using analgesic medications prior to MC [medical cannabis] treatment initiation were no longer using them. This was true for all classes of analgesic drugs including over the counter analgesics, non-steroidal anti-inflammatory drugs, anticonvulsants and antidepressants. As for opioid use, 24 percent and 20 percent of the participants who had been using weak or strong opioids, respectively, at baseline stopped using them by the time they reached the 12-month follow-up.’

They concluded, “This prospective study provides further evidence for the effects of medical cannabis on chronic pain and related symptoms, demonstrating an overall mild-to-modest long-term improvement of the tested measures and identifying possible predictors for treatment success.’

Full text of the study, “Medical cannabis treatment for chronic pain: Outcomes and prediction of response,’ appears in the European Journal of Pain.

Clinical Trial: Sublingual Administration of CBD Is Effective in Patients with Diabetic Neuropathy

West Bloomfield, MI: The administration of a proprietary, water-soluble CBD tablet mitigates neuropathic foot pain compared to placebo, according to randomized clinical trial data published in the Journal of Diabetes & Metabolism.

Researchers affiliated with Pure Green Pharmaceuticals assessed the efficacy of sublingual CBD tablets (20mg) versus placebo in a cohort of subjects with painful diabetic peripheral neuropathy (pDPN) pain in their feet. Subjects were administered either the active drug or a placebo three times per day for 28 days.

Those taking the active drug reported significant reductions in pain compared to placebo and no adverse side-effects. Subjects taking CBD also reported improvements in their sleep quality and reduced levels of anxiety.

Authors concluded: “This 28-day trial revealed statistically and clinically significant improvement in pain and a clinically significant improvement in sleep quality and in anxiety reduction for those in the CBD treatment group. Additionally, subjects taking CBD affirmed these results by having a statistically significant greater response to treatment as compared with subjects taking placebo. The benefit of this study demonstrates that the sublingual 20 mg CBD tablet should be considered as a safe and effective treatment for pDPN.’

Numerous placebo-controlled clinical trials similarly document the ability of whole-plant cannabis to mitigate neuropathic pain in a wide range of patient populations, including in subjects with HIV and diabetes.

Full text of the study, “Cannabidiol for the treatment of painful diabetic peripheral neuropathy of the feet: A placebo-controlled, double-blind, randomized trial,’ appears in the Journal of Diabetes & Metabolism.

Marijuana Legalization Laws Don’t Undermine Tobacco Smoking Prevention Efforts

Columbus, OH: State-level changes to the legal status of cannabis have not limited the effectiveness of anti-tobacco smoking efforts targeting young adults, according to data published in the journal Nicotine & Tobacco Research.

A team of investigators with Ohio State University and with Purdue University in Indiana assessed the impact of medical cannabis access laws and adult-use legalization laws on cigarette smoking patterns among young adults.

They reported, “Cannabis policy liberalization is not associated with individual-level patterns of cigarette use.’

Authors concluded: “[T]he liberalization of cannabis laws does not disrupt gains made through the implementation of tobacco control policies. Also, we see no evidence that liberalized cannabis policies are directly associated with increased smoking behaviors among young adults. Within a context of rapidly changing cannabis policies throughout the U.S. and several countries, these results provide positive news that newly implemented cannabis laws may not adversely affect tobacco control efforts that have reduced cigarette use among young people.’

The findings differ from those of an unpublished working paper by a pair of students at the University of Texas, Dallas which contends that cigarette sales have slightly increased in some adult-use legalization states.

Full text of the study, “Further consideration of the impact of tobacco control policies on young adult smoking in light of the liberalization of cannabis policies,’ appears in Nicotine & Tobacco Research.

Survey: Over 90 Percent of Chronic Pain Patients Report Mitigating Their Use of Opioids

Tel Aviv, Israel: The overwhelming majority of pain patients provided medical cannabis treatment report either reducing or ceasing their use of opioid medications, according to data published in the Journal of Addictive Diseases.

A team of Israeli investigators affiliated with Tel Aviv University assessed the relationship between cannabis and opioids in a cohort of patients with non-cancer specific chronic pain. All of the patients enrolled in the study were prescribed medical cannabis therapy in accordance with Israel’s medical cannabis access laws.

Among those patients who reported using opioids at baseline, 93 percent either “decreased or stopped [using] opioids following cannabis initiation’ – a finding that is consistent with dozens of other studies.

Full text of the study, “Risk and benefit of cannabis prescription for chronic non-cancer pain,’ appears in the Journal of Addictive Disorders.

Case Report: Cannabis Associated with Improvements in a Patient with Refractory Stuttering

Warsaw, Poland: The use of herbal cannabis is associated with marked improvements in a patient with treatment-resistant stuttering, according to a case report published in the journal Cannabis and Cannabinoid Research.

A team of investigators affiliated with the Medical University of Warsaw (Poland) and with Hannover Medical School (Germany) presented the case of a 20-year-old male patient with refractory stuttering. Following the daily administration of vaporized plant cannabis, the patient exhibited sustained improvements in speech fluency and also reported benefits to his overall quality of life. The patient did not report any adverse side effects from cannabis over the one-year observational period.

Authors reported: “[T]his is the first case report of a patient suffering from impairing and treatment-resistant stuttering, who markedly improved after treatment with medicinal cannabis. Based on patient’s self-report and reports of family and friends, as well as several established assessments, use of cannabis resulted not only in an improvement of stuttering but also remission of (social) anxiety, and reduced depression and stress, as well as improved sleep, attention, concentration, self-confidence, social life, and overall quality of life without any side effect. Importantly, treatment effects did not decrease over time.’

They concluded, “Medicinal cannabis could be effective in treatment of refractory stuttering, but these preliminary data have to be confirmed in controlled studies.’

While this is the first case report specific to the efficacy of cannabis in the case of a patient with a stuttering disorder, several prior studies have documented the ability of THC to improve symptoms in patients with Tourette Syndrome.

Full text of the study, “Cannabis improves stuttering: Case report and interview with the patient,’ appears in Cannabis and Cannabinoid Research.

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:: FYi FB/iG Terminated WC Accts Again ::
:: No Just Cause FB iS Run By Sociopaths ::
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New directory with maps etc. in development….


Ask about our current promotion, which is a free listing with purchase of any other service @WeedConnection. Recently started rebuilding our global database and added a new/temp delivery section to our directory. Send us an email to submit any current information. Click here for listing and advertising information. The directory is a huge project that requires maintenance. We still have big plans for future development and production. Join(t) the team as a regional manager, college intern, street team member, or click here for a list of other open positions. Support, subscribe, follow, share, like, and mention growing cannabis business @WeedConnection

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Proximity to Marijuana Retailers Doesn’t Influence Young People’s Intention to Use Cannabis

Santa Monica, CA: Young adults who live near state-licensed marijuana retailers are no more likely to express an intention to use either cannabis or tobacco than those who do not, according to data published in The Journal of Cannabis Research.

Researchers with the RAND Corporation and with the University of Southern California assessed the relationship between the density of marijuana retailers and subjects’ intentions to use either cannabis or tobacco in a cohort of young adults (ages 18 to 23) living in Los Angeles county.

Authors reported, “Living near more outlets of any type was not significantly associated with intentions to use in the full sample, adjusting for individual- and neighborhood-level characteristics.”

They concluded: “This is the first study to simultaneously examine the density of both MCDs [medical cannabis dispensaries] and RCRs [recreational cannabis retailers] around young adults’ homes and associations with future intentions to use cannabis, including the co-use of cannabis with tobacco/nicotine. Our results suggest that young adults who lived in an area with a greater density of any type of outlet were not significantly more likely to report stronger intentions to use cannabis, e-cigarettes, or cannabis mixed with tobacco/nicotine in the future.”

Their findings are consistent with those of prior studies similarly concluding that the prevalence of cannabis retailers is not positively associated with increases in either marijuana use or access among younger people.

Full text of the study, “Density of medical and recreational cannabis outlets: racial/ethnic differences in the association with young adult intentions to use cannabis, e-cigarettes, and cannabis mixed with tobacco/nicotine,” appears in The Journal of Cannabis Research.

Canada: No Uptick in Trauma Patients Testing Positive for Cannabis Post-Legalization

London, Canada: The enactment of adult-use marijuana legalization is not associated with any immediate uptick in the percentage of trauma patients testing positive for past cannabis exposure, according to data published in the Canadian Journal of Surgery.

A team of researchers with Western University in London, Ontario evaluated adults admitted into a leading Canadian trauma center in the three months immediately prior to and immediately following legalization. Subjects were screened for the presence of cannabis metabolites upon admission. Most patients were admitted to the trauma unit following motor vehicle collisions.

Investigators reported: “We found that the rate of positive cannabinoid screen results among patients with trauma referred directly to our trauma service was similar in the 3 months before and [in] the 3 months after the legalization of recreational cannabis in Canada. … In the subgroup of patients whose mechanism of trauma was a motor vehicle collision, there was no difference in the rate of positive toxicology screen results or positive cannabinoid screen results between the two periods.”

They concluded, “These preliminary single-center data showing no increased rates of cannabis use in patients with trauma after legalization are reassuring.”

The data is consistent with prior studies showing no significant changes in traffic safety in the months immediately following the enactment of adult-use legalization. However, separate assessments evaluating longer-term trends in traffic safety following legalization have yielded mixed results.

Full text of the study, “Drug use in Canadian patients with trauma after cannabis legalization,” appears in the Canadian Journal of Surgery.

Daily Cannabis Use Associated with Reduced Neuroinflammation in HIV Patients

San Diego, CA: HIV+ patients who consume cannabis on a daily basis possess lower levels of neuroinflammation as compared to non-users, according to data published in the Journal of the International Neuropsychological Society.

Investigators with the University of California, San Diego evaluated the relationship between cannabis use and CNS (central nervous system) inflammation in a cohort of patients with and without HIV.

Researchers reported that HIV+ subjects who consumed cannabis daily possessed lower levels of chronic inflammation than did HIV+ subjects who abstained from marijuana. Further, users’ results were similar to those of HIV- subjects with no history of cannabis use.

Daily consumers also achieved better on measurements of cognitive performance than did those HIV+ patients with no history of regular use – a finding that is consistent with prior analyses of HIV+ patients.

Authors concluded, “Taken together, findings are consistent with the notion that cannabinoids may modulate inflammatory processes in PWH [patients with HIV], specifically in the CNS, and suggest a link between lower CNS inflammation and better neurocognitive function. … Future studies in PWH are needed to investigate potential distinct effects of specific cannabinoids, and adult medicinal use, on brain structure and function.”

Full text of the study, “Daily cannabis use is associated with lower CNS inflammation in people with HIV,” appears in the Journal of the International Neuropsychological Society.

Study: Cannabis Use Not Linked to Motivation Loss

Miami, FL: Marijuana use by teens is not independently associated with an increased risk of so-called ‘Amotivational syndrome,” according to longitudinal data published in the Journal of the International Neuropsychological Society.

A team of researchers affiliated with Florida International University assessed the association between cannabis use and motivation in a cohort of 401 adolescents (ages 14 to 17) over two years.

Authors reported that adolescents’ cannabis use was not associated with any significant changes in motivation, apathy, or engagement after investigators controlled for subjects’ use of alcohol and tobacco, among other potential confounders (such as age, sex, and depression).

They reported, “[D]espite significant increases in levels of cannabis use in our sample, change in cannabis use did not predict changes in motivation, which suggests that cannabis use may not lead to reductions in motivation over time.”

The study’s authors concluded: “Our findings do not support a relationship between cannabis use and reductions in motivation over time in a sample of adolescents at risk for escalation in cannabis use. … The current study contributes to the extant literature by examining these associations longitudinally in a large sample of adolescent cannabis users while controlling for important and often overlooked confounds, including sex and depression. … Future studies should continue to examine these associations longitudinally to determine whether heavier levels of cannabis use lead to reductions in motivation, and whether these reductions may be responsible for poorer educational and later life outcomes.”

Full text of the study, “Evidence lacking for cannabis users slacking: A longitudinal analysis of escalating cannabis use and motivation among adolescents,” appears in the Journal of the International Neuropsychological Society.

Analysis: Tax Increases on Cigarettes Don’t Influence Youth Marijuana Use

Bozeman, MT: Tax measures enacted to increase the costs of cigarettes do not inadvertently influence more young people to switch to marijuana, according to data published in the National Tax Journal.

A trio of economists assessed whether increased taxes on cigarettes influenced young adults to gravitate toward marijuana instead.

They reported, “The spillover effect of cigarette taxes on youth marijuana use has been the subject of intense public debate. Opponents of cigarette taxes warn that tax hikes will cause youths to substitute toward marijuana. … We find little evidence to suggest that teen marijuana use is sensitive to changes in the state cigarette tax.”

Authors also analyzed the effect of medical and recreational marijuana legalization laws upon youth cigarette and cannabis use. Consistent with prior studies, they reported, “We find that both state MMLs [medical marijuana laws] and RMLs [recreational marijuana laws] are associated with decreases in teen marijuana consumption, consistent with the hypothesis that selling to minors becomes a relatively risky proposition for licensed marijuana dispensaries.”

Full text of the study, “Cigarette taxes and teen marijuana use,” is available from the National Tax Journal.

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