Tag: Weed Connection

Trump Says Cannabis Rescheduling Decision Is Forthcoming

Washington, DC: President Donald Trump affirmed at a news conference Monday that his administration is “looking” at federally reclassifying cannabis and that it would “make a determination over the next few weeks.”

He said that the subject is “complicated.” While he acknowledged hearing “great things” about cannabis’ medical utility, he also said that he’s heard “bad things having to do with just about everything else [about marijuana].”

The President’s remarks were in response to a question from a news reporter. They are his first public statements about cannabis policy since winning the election.

The Biden Administration initiated the regulatory process to review cannabis’ federal classification in late 2022 — marking the fifth time that an administrative petition to remove cannabis from Schedule I had been filed, but the first time that the White House had ever led such an effort.

The following year, the US Department of Health and Human Services recommended that the Drug Enforcement Administration reclassify cannabis from Schedule I to Schedule III of the Controlled Substances Act. The DEA called for hearings on the matter, which were scheduled to begin earlier this year. Those hearings were stayed following allegations that the DEA had engaged in inappropriate and biased acts that warranted their disqualification from the proceedings.

There has been no further movement on the matter since January.

In a Truth Social post in September, Trump wrote, “As President, we will continue to focus on research to unlock the medical uses of marijuana to a Schedule 3 drug, and work with Congress to pass common sense laws, including SAFE banking for state authorized companies, and supporting states’ rights to pass marijuana laws.”

Analysis: Cannabis Dispensary Openings Associated With Fewer Opioid Deaths

Atlanta, GA: Counties with licensed cannabis dispensaries experience a reduction in opioid-related fatalities as compared to those without regulated marijuana access, according to an analysis of federal data published in The Washington Post.

The analysis measured county-level dispensary openings and trends in opioid-related deaths. The author reported: “When a county opens its first dispensary — giving residents easy access to marijuana – opioid death rates go down relative to counties that don’t yet have any dispensaries. The effects aren’t small, either. Ten years after that first dispensary opens, death rates in cannabis counties are, on average, about 30 percent lower than death rates in counties without a dispensary.”

He added, “The fact that the drop in deaths shows up right after the first dispensary opens – and not before – strongly suggests that opioid users do shift to marijuana, at least enough to stop overdosing.”

The findings are consistent with those of other studies reporting that increases in the volume of medical and recreational storefront dispensaries are associated with reduced opioid-related mortality rates.

Studies also report that opioid-dependent subjects acknowledge using cannabis to reduce drug cravings and mitigate withdrawal symptoms.

The analysis, “Data shows a new remedy for the opioid crisis,” is available from The Washington Post.

Canada: Nearly Eight in Ten Consumers Say They Obtain Cannabis Exclusively From Legal Markets

Waterloo, Canada: Most Canadian cannabis consumers have transitioned to the legal marketplace following nationwide legalization, according to survey data published in the journal Drug and Alcohol Review.

An international team of investigators from Canada, the United States, and the United Kingdom assessed trends in marijuana-related purchases among 2,686 current cannabis consumers.

Seventy-eight percent of respondents said that “all their cannabis came from legal sources in the past year.”

The data is consistent with prior studies finding that most Canadian consumers have transitioned from the unregulated market to the legal adult-use marketplace following legalization.

Researchers attribute consumers’ transition to falling prices. “Prices of legal cannabis products have decreased substantially over the first 5 years after federal legalization in Canada, with a narrowing differential between the cost of legal and illegal products,” they reported.

The study’s authors concluded: “These findings demonstrate a consistent and substantial transition to legal retail sources in Canada over the first 5 years of legalization, … reflecting considerable progress towards Canada’s objective of displacing illegal sources through the creation of a legal cannabis market.”

Data compiled in the United States similarly reports that a growing percentage of consumers are switching to the legal marketplace. According to a 2023 survey, 52 percent of consumers residing in legal states said that they primarily sourced their cannabis products from brick-and-mortar establishments.

A separate US economic study reports that consumers are most likely to transition to the legal marketplace in jurisdictions where state-licensed retailers are widely available. According to the study’s findings, “States with roughly 20 to 40 legal regulated stores per 100,000 residents, in general, have captured 80 percent to 90 percent of all cannabis sales in the legal market.”

Full text of the study, “Self-reported cannabis prices and expenditures from legal and illegal sources five years after legalization of non-medical cannabis in Canada,” appears in Drug and Alcohol Review.

Preclinical Study: CBD Dosing Mitigates Cravings for Alcohol

San Diego, CA: CBD administration reduces alcohol intake and alcohol-associated withdrawal symptoms in rodents, according to preclinical data published in the journal Nature: Neuropsychopharmacology.

Investigators affiliated with the University of California at San Diego assessed the effects of CBD dosing on alcohol-dependent rats. They reported that CBD mitigated alcohol intake, prevented alcohol-induced damage to the brain, and attenuated relapse-like behaviors.

“The present study demonstrates that chronic administration of cannabidiol attenuates both behavioral and neurobiological manifestations of alcohol dependence in rodent models,” authors concluded. “Specifically, CBD reduced alcohol intake and withdrawal symptoms, lowered relapse-like behaviors, normalized neuronal excitability in the basolateral amygdala (BLA), and prevented alcohol-induced neurodegeneration in striatal regions associated with reward and habit formation. … These results underscore CBD’s potential therapeutic utility for alcohol use disorder (AUD) and provide mechanistic insights into its actions.”

Placebo-controlled clinical data published earlier this year concluded that the oral administration of 800 mg of synthetic CBD significantly reduces subjects’ cravings for alcohol. A 2021 observational study determined that the consumption of CBD-dominant cannabis is associated with reductions in subjects’ alcohol intake. The authors of that study reported that participants who ingested CBD-dominant cannabis during the trial period “drank fewer drinks per drinking day, had fewer alcohol use days, and fewer alcohol and cannabis co-use days” compared with those who did not.

According to 2024 survey data, 60 percent of cannabis consumers say that using cannabis leads to less alcohol consumption.

Full text of the study, “Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum,” appears in Nature:Neuropsychopharmacology.

Federal: Language Facilitating Medical Cannabis Access for Veterans Included in Senate, House Versions of Military Spending Bill

Washington, DC: Members of the US Senate and the House of Representatives have approved amendments allowing physicians affiliated with the Department of Veterans Affairs to recommend medical cannabis to qualified patients in jurisdictions that regulate its use.

Federal regulations currently preclude physicians associated with the Veterans Affairs Department from filling out the paperwork necessary to issue a state-authorized medical marijuana recommendation. The pending language amends these rules so that no federal funds may be used to prohibit physicians from engaging in the medical marijuana authorization process.

The new provisions are included in the House and Senate versions of a much broader legislative package, the Military Construction, Veterans Affairs, and Related Agencies Appropriations Act. However, because the two chambers have approved differing versions of the Act, members must still reconcile the language of the two bills. That process typically takes place in a conference committee.

In prior years, lawmakers have removed similar cannabis reform language from the Military Construction bill during the conference committee process.

Lawmakers are anticipated to take further action on the Act shortly after reconvening from their August recess.

Study: Medical Cannabis Associated With Health-Related Quality of Life Improvements, Reduced Opioid Use Among Patients With Substance Use Disorders

London, United Kingdom: Patients diagnosed with substance use disorders (SUD) report improved sleep quality, reduced anxiety, and decreased opioid use following the sustained use of medical cannabis products, according to observational data published in the journal European Addiction Research.

British investigators assessed the use of cannabis-based medicinal products (CBMPs) in SUD patients enrolled in the UK Medical Cannabis Registry. (British health care providers may prescribe cannabis-based medicinal products to patients unresponsive to conventional medications.) More than half (53 percent) of the participants suffered from an opioid use disorder. Patients’ outcomes were assessed at one, three, and six months.

“[T]herapy with CBMPs in patients with SUDs was associated with improvements in [patients’] anxiety, sleep quality and HRQoL [health-related quality of life] at 1, 3 and 6 months,” investigators reported. “Additionally, treatment with CBMPs was associated with a reduction in the median daily OME [oral morphine equivalent] from baseline to 6 months with no severe or life-threatening adverse events reported. These findings are in line with similar studies and broader data from the UK Medical Cannabis Registry for other conditions.”

The study’s authors concluded: “In the context of SUD, CBMPs may … play a role in the maintenance therapy of opiate-dependent individuals with co-morbid anxiety and sleep disorders or symptoms. … CBMPs may also play a role during tapering of opioid doses during maintenance therapy due to the prevalence of anxiety and sleep disruption in individuals experiencing withdrawal from medications. … Although capturing a 6-month follow-up is valuable, longitudinal data to see if PROMs [patient-reported outcome measures] would stay the same, improve further or instead decline would also prove useful in strengthening the evidence base for CBMPs in the treatment of substance use disorders.”

Survey data have previously reported that a significant percentage of patients undergoing opioid maintenance therapy acknowledge consuming cannabis to ease withdrawal symptoms and drug cravings.

Other observational studies assessing the use of cannabis products among those enrolled in the UK Medical Cannabis Registry have reported them to be effective for patients diagnosed with treatment-resistant epilepsy, cancer-related pain, anxiety, fibromyalgia, inflammatory bowel disease, hypermobility disorders, depression, migraine, multiple sclerosis, osteoarthritis, and inflammatory arthritis, among other conditions.

Full text of the study, “UK Medical Cannabis Registry: A clinical analysis of patients with substance use disorder,” appears in the European Addiction Research.

Study: Patients Engage in Compensatory Driving Behaviors Following Ingestion of THC Extracts

Queensland, Australia: Patients who consume oral doses of THC drive at slower speeds and engage in other compensatory behaviors, according to driving simulator data published in the journal Psychopharmacology.

Australian researchers assessed subjects’ simulated driving performance prior to and 90 minutes after their ad libitum consumption of prescribed THC oil extracts. (Australian physicians may prescribe cannabis products to patients unresponsive to conventional prescription treatments.) On average, study subjects consumed 11 mg of THC prior to driving.

Similar to the results of prior studies, subjects engaged in compensatory driving behaviors – such as driving at slower speeds and increasing the distance between their vehicle and the vehicles in front of them – following THC dosing. Few other changes in participants’ baseline performance were identified, leading investigators to presume that patients likely become tolerant to THC’s potential effects on cognitive and psychomotor performance.

“Our results align with a growing body of evidence demonstrating that chronic THC use can mitigate the acute effects of the substance on driving performance and driving-related cognitive functions,” researchers reported.

The study’s authors concluded: “Taken together, our findings suggest that … medicinal cannabis users may … be more inclined to compensate for cannabis impairment through alterations in speed and following distance. … Future research is needed to further investigate the effects of THC on these driving-related skills and behaviors using a wider range of doses and administration methods, with populations of varying tolerance levels.”

The study’s findings are consistent with those of several others, determining that daily cannabis consumers, and patients especially, exhibit tolerance to many of cannabis’ psychomotor-influencing effects. According to the findings of a literature review published in the Journal of the German Medical Association, “Patients who take cannabinoids at a constant dosage over an extensive period of time often develop tolerance to the impairment of psychomotor performance, so that they can drive vehicles safely.”

Full text of the study, “The effects of orally ingested delta-9-tetrahydrocannabinol on drivers’ hazard perception and risk-taking behaviors: A within-subjects study of medicinal cannabis users,” appears in Psychopharmacology.

Analysis: Cannabis Use Not Associated with Elevated Risk of Kidney Disease

Baltimore, MD: Adults with a history of cannabis use do not possess an elevated risk of kidney disease at midlife, according to longitudinal data published in the journal Cannabis and Cannabinoid Research.

A team of investigators affiliated with Johns Hopkins University School of Medicine in Baltimore and Tulane University in New Orleans assessed the relationship between cannabis use and kidney function. Study participants included current cannabis consumers and non-users. Participants were assessed at baseline and again nearly a decade later.

“Compared with those with no history of cannabis use, participants with current regular cannabis use were not at higher risk of incident CKD [chronic kidney disease] (OR: 0.79), rapid kidney function decline (OR: 0.80) or incident albuminuria [the presence of albumin in urine, a symptom of kidney disease (OR: 0.84) after adjustment for [confounders],” researcher reported.

The study’s authors concluded, “[T]here was no independent association between cannabis use and adverse kidney outcomes over time.”

Full text of the study, “Evaluating the association of cannabis use and longitudinal kidney outcome,” appears in Cannabis and Cannabinoid Research.

Analysis: Marijuana Legalization in California Associated With Lower Alcohol Consumption

San Francisco, CA: The passage of adult-use marijuana legalization in California is associated with sustained decreases in alcohol consumption, according to data published in the journal Addiction.

Researchers affiliated with the University of California, San Francisco and the healthcare provider Kaiser Permanente assessed trends in self-reported alcohol consumption among northern Californians prior to and following voters’ decision to legalize marijuana. (California legalized marijuana in 2016.) Study participants were Kaiser Permanente patients who underwent annual screenings for alcohol use during visits with their primary care doctors. Investigators reviewed data from over 3.5 million adults over four years.

Researchers identified sustained declines in participants’ weekly drinking patterns, as well as in how often they engaged in heavy episodic drinking, following legalization. Declines were most pronounced among those ages 35 to 49.

“Specifically, this group showed a significant immediate reduction in frequent HED [heavy episodic drinking], along with gradual declines over time in HED and rates of exceeding both daily and weekly limits,” investigators determined. “This may suggest that cannabis policy changes contributed to a meaningful shift away from higher risk drinking behaviors, potentially reflecting greater substitution effects as compared to younger groups.”

Declines were less pronounced among those ages 21 to 34 and among those 65+.

The study’s authors concluded, “Cannabis policy changes in California, USA, appear to be linked to age-specific changes in alcohol use, with moderate reductions, particularly among middle-aged adults.”

The findings are consistent with those from Canada determining that alcohol sales declined in that country following the adoption of adult-use marijuana legalization.

Survey data published last year in The Harm Reduction Journal found that 60 percent of cannabis consumers acknowledge using it to reduce their alcohol intake.

Full text of the study, “Are cannabis policy changes associated with alcohol use patterns? Evidence from age-group differences based on primary care screening data,” appears in Addiction.

Survey: IBD Patients Report Symptomatic Benefits, Decreased Reliance on Opioids Following Cannabis Use

Cleveland, OH: Patients with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, frequently report using cannabis products to manage their symptoms, according to survey data published in the journal Academia Medicine.

Investigators affiliated with the Case Western Reserve School of Medicine surveyed 93 IBD patients regarding their use of either cannabis or CBD products.

Among those participants who acknowledged consuming cannabis, most said that it mitigated their IBD-related pain, stress, and anxiety. Many patients also reported using CBD oil products; however, they did not perceive them to be as effective as cannabis.

Thirty-four percent of patients reported decreasing their opioid consumption when using either cannabis or CBD products – a finding that is consistent with prior data. Fifteen percent of patients reported that their use of cannabis products induced disease remission.

“The findings indicate that a significant proportion of IBD patients use cannabis, notice symptom relief, and prefer its therapeutic use,” the study’s authors concluded. “As interest in alternative treatments gains momentum, these results can influence future clinical trials, guide healthcare professionals in patient counseling, and be included in altering treatment modalities.”

Observational trials have previously documented that cannabis use by IBD patients is associated with fewer ER visits. In a randomized placebo-controlled trial involving 21 patients with refractory Crohn’s disease, nearly half achieved disease remission following their use of herbal cannabis. A separate placebo-controlled trial reported that herbal cannabis is associated with clinical improvements and increased quality of life in patients with mild to moderate ulcerative colitis.

Full text of the study, “Inflammatory bowel disease patients believe cannabis and cannabidiol oil relieve symptoms,” appears in Academia Medicine.

Delaware: Medical Cannabis Dispensaries To Begin Adult-Use Sales

Dover, DE: Consumers ages 21 and older can begin purchasing cannabis products from licensed retailers on Friday, August 1st – some 28 months after lawmakers approved legislation legalizing the adult-use market.

Consumers will initially be able to purchase cannabis at approximately a dozen retail locations — all of which are existing medical cannabis dispensaries that have received ‘conversion licenses’ to sell to patients and adults.

Regulators have pledged to approve additional licenses to new applicants in the coming months.

“Delaware has taken a major step forward by launching a legal adult-use cannabis market that prioritizes equity, safety, and accountability,” Democratic Governor Matt Meyer said. “This new industry will generate critical revenue to strengthen our schools, infrastructure, and public health systems, while creating real opportunities for entrepreneurs. This revenue also gives us a powerful tool to invest in the communities most impacted by the war on drugs, addressing past wrongs and ensuring that the benefits of this new market reach every corner of our state.

A Delaware State Auditor’s report estimates that adult-use sales will generate $43 million in annual tax revenue.

Survey: Patients Undergoing Opioid Maintenance Therapy Frequently Use Cannabis To Mitigate Cravings, Withdrawal Symptoms

Munich, Germany: A significant percentage of patients undergoing opioid maintenance therapy (OMT) acknowledge consuming cannabis to ease withdrawal symptoms and drug cravings, according to survey data published in the journal Brain Sciences.

German researchers affiliated with the University of Munich surveyed 128 opioid use disorder (OUD) patients receiving OMT. Forty-one percent of respondents reported using cannabis. Of those, 59 percent said that they did so “to suppress cravings for other [controlled] substances.” Thirty-nine percent said they used cannabis “to suppress opioid withdrawal symptoms.”

The findings are consistent with prior studies involving opioid-dependent subjects.

“These findings highlight a complex interaction between opioid treatment and cannabis use,” the study’s authors concluded. “Further longitudinal and placebo-controlled trials are needed to investigate the clinical and pharmacological interactions between cannabis and OMT, including effects on craving, withdrawal, and overall treatment outcomes.”

Full text of the study, “Cannabis use in opioid maintenance therapy: Prevalence, clinical correlates, and reasons for use,” appears in Brain Sciences.