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Study: Cannabis Products Associated With Improvements in Patients With Attention-Deficit/Hyperactivity Disorder

London, United Kingdom: Patients with attention-deficit/hyperactivity disorder (ADHD) exhibit sustained improvements in their symptoms following the use of cannabis products, according to data published in the journal Neuropsychopharmacology Reports.

British investigators assessed the safety and efficacy of plant-derived cannabis products (either oils, flower, or a combination of both) in a cohort of 68 patients enrolled in the UK Medical Cannabis Registry. Participants possessed a doctor’s authorization to access cannabis products. (Since 2018, specialists have been permitted to prescribe cannabis-based medicinal products to patients unresponsive to conventional medications.) Authors assessed the efficacy of cannabis at one, three, six, and twelve months.

Researchers reported improvements in patients’ anxiety, sleep quality, and overall health-related quality of life following cannabis treatment. Over one-third of patients ceased taking at least one ADHD prescription drug medication over the course of the study.

The study’s authors concluded: “This case series is the first of its kind in assessing the clinical outcome of patients from the UKMCR with a primary diagnosis of ADHD prescribed CBMPs [cannabis-based medicinal products] for up to 12 months. This study reports that treatment with CBMPs was associated with improvements in general HRQoL [health-related quality of life] after 1, 3, and 6, months, in addition to anxiety and sleep quality after 1, 3, 6, and 12 months. These results suggest that CBMPs may play a role in alleviating symptoms and co-morbid anxiety and sleep disruption associated with ADHD.”

Prior studies assessing the use of cannabis products in patients enrolled in the UK registry have reported them to be effective for those suffering from chronic pain, post-traumatic stress, depression, generalized anxiety, migraine, inflammatory bowel disease, and other afflictions.

Full text of the study, “An analysis of clinical outcomes of medicinal cannabis therapy for attention-deficit/hyperactivity disorder,” appears in Neuropsychopharmacology Reports.

Congressional Representatives Introduce Legislation Protecting State Marijuana Laws From Federal Interference

Washington, DC: A bipartisan coalition of House lawmakers have introduced legislation, the Strengthening the Tenth Amendment Through Entrusting States (STATES) Act, protecting state-level marijuana legalization laws and allowing for the interstate commerce of cannabis products between legal states.

“The current federal approach to cannabis policy infringes on the rights of states to implement their own laws, stifling critical medical research, hurting legitimate businesses, and diverting vital law enforcement resources needed elsewhere,” said Rep. David Joyce (R-OH), co-chair of the Congressional Cannabis Caucus and the lead sponsor of the bill. “The STATES Act does what every federal bill should do – help all 50 states succeed. This bill respects the will of the states that have legalized cannabis in some form and allows them to implement their own policies without fear of repercussion from the federal government.”

Congressman Joyce is joined by Reps. Earl Blumenauer (D-OR), Troy Carter (D-LA), Rep. Lori Chavez-Remer (R-OR), and Brian Mast (R-FL). A more limited version of the STATES Act was initially introduced in Congress in 2018.

The STATES Act is one of several House bills, including the States Reform Act and the Marijuana Opportunity, Reinvestment and Expungement (MORE) Act, that seek to remove marijuana from the scheduling system established by the Controlled Substances Act. However, it is unlikely that newly elected House Speaker Mike Johnson (R-LA) will prioritize any of these measures. Representative Johnson has repeatedly voted against proposed legislative changes in federal marijuana policy, and he has criticized Democratic leadership for advancing cannabis reform measures, particularly The MORE Act.

Missouri: 100,000 Marijuana Convictions Expunged Following Legalization

Columbia, MO: State officials over the past year have expunged the records of more than 100,000 marijuana-related cases, according to data highlighted by Missouri NORML.

Provisions included in the state’s voter-approved adult-use legalization law, which took effect on December 8, 2022, provided a one-year timeline for the expungement of marijuana-related convictions. Since then, over 100,000 cases have been expunged, says Dan Viets – a NORML Board Member and a co-author of the law.

“This automatic expungement of marijuana cases is one of the most significant parts of Article XIV,” he said. “In addition to stopping approximately 20,000 marijuana arrests each year, the law now requires state government to undo much of the damage which was inflicted on hundreds of thousands of Missourians during the past 100 years.”

Viets predicted that additional cases would be expunged in the future. “The courts are going to need more time to finish the job, and in fact, it might be years before all the cases from the past century are expunged,” Viets acknowledged. “We’ve had more than 100 years of marijuana prohibition in Missouri. Many of the older cases have never been put on a database. So, it’s going to take a lot of physical work to locate those paper records in boxes and attics and go through them.”

Twenty-four states and the District of Columbia have enacted laws providing explicit pathways to either expunge (or otherwise set aside) the records of those with low-level marijuana convictions. According to publicly available data compiled by NORML, state and local officials have issued over 100,000 pardons and more than 1.7 million marijuana-related expungements since 2018.

Review the full text of the NORML Report, Marijuana Pardons and Expungements: By the Numbers.

Georgia: DEA Sends Warning Letters to Independent Pharmacies Seeking To Dispense State-Licensed Cannabis Products

Washington, DC: A recent letter from the US Drug Enforcement Administration is warning pharmacies that they may not legally engage in the dispensing of non-FDA-approved marijuana products.

The letter, dated November 27th, comes just weeks after several Georgia pharmacies applied with the state’s Board of Pharmacy to dispense state-approved plant-derived low-THC products.

Low-THC/high CBD products have been legal to possess under state law since 2015. However, regulators failed to approve licensed providers or dispensaries until earlier this year. Last month, a handful of independent pharmacies reportedly began dispensing cannabis products to qualified patients. About 14,000 Georgians are registered to access cannabis products for a variety of ailments, including autism, cancer, Crohn’s disease, seizure disorders, and Tourette syndrome.

The DEA letter states: “A DEA-registered pharmacy may only dispense controlled substances in Schedules II-V of the Controlled Substances Act. Neither marijuana nor THC can lawfully be possessed, handled, or dispensed by any DEA-registered pharmacy.”

By contrast, the letter acknowledges that products derived from hemp plants containing 0.3 percent THC or less may be sold on store shelves because they are no longer regulated under the Controlled Substances Act.

Local news outlets have reported that some pharmacies have abandoned plans to dispense low-THC products after receiving the letter.

Regulators pushed to allow independent pharmacies to stock plant-derived cannabis products because there are so few licensed dispensaries currently operating in the state.

Ohio: Lawmakers Adjourn for 2023 Without Advancing Legislation Modifying State’s Newly Approved Adult-Use Legalization Law

Columbus, OH: Lawmakers held their final hearings of 2023 without taking any further legislative action on bills to modify the state’s voter-approved adult-use legalization law.

Fifty-seven percent of voters favored the ballot measure (Issue 2) in November. The law took effect on December 7th. However, because the measure was put before voters as a statutory question rather than a constitutional amendment, state lawmakers can amend or repeal its provisions.

Earlier this month, Senate President Matt Huffman introduced legislation that sought to repeal much of the law. That plan was met with resounding resistance from voters, pundits, and members of House leadership. (A NORML Action Alert urging lawmakers to respect the majority of Ohio voters’ will was sent to lawmakers over 7,500 times in 72 hours.) Senators eventually approved substitute language that largely preserves adults’ ability to possess and home-cultivate cannabis, but also prohibits Ohioans’ ability to gift marijuana to one another, amend tax rates, and impose a low THC cap on marijuana concentrates, among other changes. House members have yet to take up the Senate’s proposal and are considering their own legislation to modify certain aspects of the new law.

Lawmakers in both chambers are anticipated to revisit the issue when they reconvene in January.

Any modifying legislation passed by lawmakers will not take effect until 90 days after it is signed into law.

Cleveland: City Officials Ending Pre-Employment Testing for Cannabis

Cleveland, OH: City officials have removed pre-employment drug screening requirements for many public employees.

Officials announced the municipal policy change on Thursday, the same day provisions of a voter-approved marijuana legalization measure (Issue 2) took effect.

Under the new rules, public employees will only undergo pre-employment drug tests if they apply for certain safety-sensitive positions, such as fire-fighters, police officers, and emergency responders.

“Pre-employment screening can often create obstacles in filling open positions by preventing otherwise qualified candidates from even applying,” city officials stated in a press release. “These policy updates are more cost-effective and will ultimately help us widen the applicant pool for several city positions.”

Several other municipalities – including Atlanta, Baltimore, Philadelphia, and St. Louis – have enacted similar ordinances. Michigan, Nevada, and Washington have passed legislation halting pre-employment marijuana testing statewide. Several other states -- including California, Connecticut, Minnesota, Montana, New Jersey, New York, and Rhode Island -- have enacted broader workplace protections limiting employers’ ability to test for or sanction employees for their cannabis use while off the job.

Ohio’s new marijuana law permits adults to consume cannabis in private, but it does not amend workplace drug testing policies.

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Study: No Increase in Cannabis Use Among Older Teens Following Adult-Use Legalization

Philadelphia, PA: Those between the ages of 18 and 20 show no uptick in their use of cannabis following the adoption of statewide adult-use legalization, according to data published in the Journal of Psychoactive Drugs.

Researchers affiliated with Drexel University in Philadelphia assessed cannabis use trends in Los Angeles, California in two separate cohorts of subjects between the ages of 18 and 20. The first cohort was assessed during the years immediately prior to the adoption of adult-use legalization in California. The second cohort was assessed in 2019-2020. (California voters legalized marijuana in November 2016; retail sales began the following January.) Participants in both cohorts reported being current cannabis consumers prior to their enrollment in the study.

Investigators failed to identify any significant differences in cannabis use frequency between the two groups. However, those in the latter cohort were less likely to report consuming either alcohol or cigarettes.

The study’s authors concluded: “Despite purported greater access to cannabis during the post-AUL [adult-use legalization] period in Los Angeles, California, no significant differences in cannabis use frequency among 18–20-year-old cannabis users were observed. ... Also, the post-AUL cohort reported fewer days of alcohol and cigarette use, suggesting the possibility of a protective effect offered by cannabis. .... Future studies should monitor whether stable rates of cannabis use and declines in alcohol and cigarette use will be sustained as some participants reach legal age to access these substances for adult use, and how these trends continue or alter as participants enter later emerging adulthood.”

The study’s findings are consistent with those of several others similarly finding no significant uptick in cannabis use by young people following adult-use legalization.

Full text of the study, “Pre-post cannabis legalization for adult use: Trend study of two cohorts of young cannabis users in Los Angeles,” appears in the Journal of Psychoactive Drugs.

Study: Nighttime Cannabis Use Associated With Improved Sleep Quality

Haifa, Israel: Cannabis use prior to bedtime is associated with improved sleep quality, according to data published in the journal Drug and Alcohol Review.

Israeli investigators assessed the relationship between cannabis and self-reported sleep quality in a cohort of 347 subjects who reported suffering from anxiety. Subjects reported their quality of sleep each morning for 30 days.

Researchers reported: “Cannabis use [was] ... linked to higher perceived sleep quality versus non-use. ... These findings add to the emerging evidence of cannabis’s sleep-enhancing properties.”

The survey’s findings are consistent with those of others concluding that consumers frequently use cannabis to mitigate sleep disorders, including insomnia, and that moderate doses of cannabis improve sleep quality. Data published in the journal Complementary Therapies in Medicine previously reported that the enactment of adult-use marijuana legalization laws is associated with a significant reduction in the sales of over-the-counter sleep aids among the general public.

Full text of the study, “Daily diary study of associations between alcohol, cannabis, co-use and sleep quality in individuals with intentions to use cannabis to cope with anxiety,” appears in Drug and Alcohol Review.

Florida: Majority of Voters Approve of Proposed Adult-Use Legalization Ballot Measure

Tallahassee, FL: Sixty-seven percent of Florida voters support a proposed constitutional amendment to legalize the adult-use possession and retail sale of marijuana, according to statewide polling data compiled by the University of North Florida.

Pollsters reported that 78 percent of Democrats, 69 percent of non-affiliated voters, and 55 percent of Republicans back the plan. Support is strongest among younger voters (86 percent). Most seniors (51 percent) also endorse the plan.

Advocates for the proposed amendment, Smart & Safe Florida, have already collected a sufficient number of signatures to place it on the 2024 ballot. However, the state’s Attorney General, Republican Ashley Moody, has asked the Supreme Court to disqualify the measure. The Court heard oral arguments in the case last month.

Florida’s Attorney General successfully brought suit in 2021 to keep a similar initiative off the 2022 ballot.

The proposed initiative, which has been primarily funded by the marijuana retail company Trulieve, allows adults to possess up to three ounces of cannabis. It permits existing state-licensed medical cannabis dispensaries to serve the adult-use market, and it would authorize -- but not require -- lawmakers to license additional marijuana businesses.

Additional information is available from Smart & Safe Florida.

New Hampshire: Task Force Fails To Find Consensus on 2024 Legislative Legalization Plan

Concord, NH: Members of a state-appointed commission tasked with studying the feasibility of regulating adult-use cannabis sales in state-owned stores failed to issue policy recommendations in its final report to lawmakers.

Lawmakers in August enacted legislation establishing the task force after Republican Gov. Chris Sununu voiced support for potentially legalizing adult-use cannabis sales through state-owned stores. (State law mandates that retail sales of wine and spirits take place exclusively in state-owned ABC outlets.) The Governor had previously been an outspoken critic of legalization.

Those on the 19-member commission failed to achieve consensus on a model distribution system for cannabis sales and also failed to agree upon a number of related issues, such as proposed THC potency caps, public use penalties, and whether or not to allow adults to engage in personal home cultivation.

Currently, the possession of limited amounts of marijuana (up to ¾ of one ounce) is a civil violation in New Hampshire. It is the only state in New England that has not legalized marijuana possession and sales.

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Study: Patients Fail to Exhibit Changes in Neurocognitive Performance Following Cannabis Use

Melbourne, Australia: The use of medical cannabis is not associated with significant changes in patients’ cognitive performance or driving abilities, according to data published in the journal CNS Drugs.

Australian researchers assessed neurocognitive performance in a cohort of 40 patients authorized to use medical cannabis products. (Under Australian law, physicians may authorize cannabis products to patients unresponsive to conventional prescription treatments.) Participants’ performance was assessed at baseline and again three hours later. Patients either vaporized herbal cannabis or consumed oral extracts. Study participants had regularly used medical cannabis products for at least ten months prior to enrolling in the trial.

Patients exhibited no changes in simulated psychomotor performance, executive function, memory, or reaction time following their self-administration of a “standard dose of their prescribed medical cannabis.” Results were consistent regardless of the type of cannabis product consumed.

Investigators reported: “We found no evidence for impaired cognitive function when comparing baseline with post-treatment scores on a comprehensive neuropsychological test battery, nor did we observe any change in performance on the DRUID [psychomotor] test battery over time. … These findings are consistent with two systematic reviews published in the last year that suggest that medical cannabis, when used regularly and consistently for a chronic health condition, may have little if any impact on cognitive function.”

The study’s authors concluded, “Medical cannabis may have minimal acute impact on cognitive function when prescribed and used as directed.”

Other studies have similarly determined that habitual cannabis consumers become tolerant to cannabis-induced changes in either cognitive or psychomotor performance. According to a 2018 meta-analysis of 36 studies involving over 1,000 participants: “Available evidence suggests that the effects of acute marijuana or Δ9-THC administration are less prominent in individuals with a regular pattern of cannabis use compared to non-regular users. Cognitive function appears to be the domain most likely to demonstrate tolerance upon repeated exposure, with some evidence of full tolerance indicating a complete absence of acute effect.”

A literature review published in the journal of the German Medical Association concluded, “Patients who take cannabinoids at a constant dosage over an extensive period of time often develop tolerance to the impairment of psychomotor performance, so that they can drive vehicles safely.”

Full text of the study, “A semi-naturalistic, open-label trial examining the effect of prescribed medical cannabis on neurocognitive performance,” appears in CNS Drugs.

Survey: Consumers Prefer Cannabis Over Conventional Sleep Aids

Pullman, WA: Many consumers report using cannabis as a substitute for conventional sleep aids, including melatonin and benzodiazepines, according to survey data published in the journal Exploration in Medicine.

Researchers affiliated with Washington State University surveyed over 1,200 individuals who reported using cannabis for sleep.

More than 80 percent of respondents said that they had eliminated their use of over the counter and prescription sleep aids after switching to cannabis. Respondents were more likely to use herbal cannabis rather than edible products prior to bedtime. About half of those surveyed reported using products that contained CBD and/or the terpene myrcene. Myrcene is reported to possess sedative effects.

The survey’s findings are consistent with those of others concluding that patients frequently consume cannabis to mitigate sleep disorders, including insomnia. Data published in the journal Complementary Therapies in Medicine reports that the enactment of adult-use marijuana legalization laws is associated with a significant reduction in the sales of over the counter sleep aids among the general public.

Full text of the study, “A large-scale survey of cannabis use for sleep: Preferred products and perceived effects in comparison to over the counter and prescription sleep aids,” appears in Exploration in Medicine.

Survey: Most Cancer Patients Say Cannabis “Improves Their Ability To Cope With Their Illness”

Tel Aviv, Israel: The majority of cancer patients suffering from refractory pain say that the use of medical cannabis helps them cope with their illness, according to survey data published in the journal BMJ Supportive & Palliative Care.

Israeli researchers surveyed 138 cancer patients authorized to use cannabis products. (Medical cannabis is legal by prescription in Israel.) Thirty-eight percent of respondents said that cannabis significantly helped them to cope with their illness while 32 percent said that it “partially” helped them.

Authors concluded: “A large majority of patients using cannabis report that the therapy significantly improves their ability to cope with their illness, with almost 40 percent stating it has done so to a large extent. In this cohort of patients with intractable cancer pain that has proved minimally responsive to numerous conventional treatments, including of course powerful opioids, adjuvants and radiotherapy, this seems to be a striking response. … This ... seems to suggest that this therapy should be considered in addition to current therapies for cancer-related pain and could be offered to patients even earlier in the course of their illness and treatments than is acceptable now.”

Other studies have documented sustained improvements in pain intensity, cognition, and sleep quality among cancer patients who consume cannabis products. Cancer patients also report decreasing their use of opioids following cannabis therapy.

Full text of the study, “Medical cannabis for refractory cancer-related pain in a specialized clinical service: A cross-sectional study,” appears in BMJ Supportive & Palliative Care.

Maine: Testing Analysis Identifies Contaminants in Many Medical Cannabis Products

Augusta, ME: A significant percentage of medical cannabis products contain potentially harmful contaminants, according to an analysis performed by the state’s Office of Cannabis Policy.

State investigators collected and analyzed samples from 120 registered caregivers and dispensaries. Products analyzed included herbal cannabis and oil extracts.

Maine law does not mandate third-party lab testing for medical cannabis products. By contrast, products produced for the adult-use market are required to undergo testing prior to being sold by retailers.

Of the products tested, 42 percent contained contaminants, including yeast and mold, pesticides, and heavy metals. The presence of molds and other contaminants may pose increased risks to patients, particularly those who may be more susceptible to infection.

NORML has long opined in favor of third-party purity testing for cannabis products. It has also called for greater regulatory oversight for state-licensed testing laboratories.

Testing analyses of other unregulated cannabis products, such as those containing hemp-derived CBD and/or delta-8-THC, have similarly reported elevated percentages of heavy metals and other contaminants.

Full text of Maine’s Office of Cannabis policy report is available from the Maine Office of Cannabis Policy.

Georgia: Regulators Award Licenses to Four Additional Producers of Low-THC Cannabis Products

Atlanta, GA: State regulators have awarded cannabis production licenses to four additional companies. The licenses allow the companies to grow cannabis and manufacture low-THC/high-CBD oil products.

Low-THC/high CBD products became legal to possess in 2015. However, regulators failed to approve any licensed providers or dispensaries until earlier this year. There are now a total of six licensed producers in the state.

In November, independent pharmacies began selling cannabis oil products statewide. Medical cannabis products are also available in state-licensed dispensaries, though fewer than ten facilities are currently licensed by state officials.

About 14,000 Georgians are registered to access cannabis products for a variety of ailments, including autism, cancer, Crohn’s disease, seizure disorders, and Tourette syndrome.

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Clinical Trial: Oral CBD Administration Provides Relief From Dental Pain

San Antonio, TX: A single oral dose of plant-derived CBD provides short-term relief from acute dental pain, according to randomized, placebo-controlled trial data published in the Journal of Dental Research.

Investigators affiliated with the University of Texas at San Antonio assessed the efficacy of CBD (in the form of Epidiolex) versus placebo in a cohort of 61 patients with severe dental pain. Subjects received a dose of either 10 mg, 20 mg, or placebo CBD. A visual analog scale assessed patients’ pain levels before and after treatment.

Researchers reported, “Both CBD groups resulted in significant VAS pain reduction compared to their baseline and the placebo group, with a maximum median VAS pain reduction of 73 percent from baseline pain at the 180-min time point.” Side-effects associated with CBD were “minimal.”

Authors concluded: “This randomized trial provides the first clinical evidence that oral CBD can be an effective and safe analgesic for dental pain. … This novel study can catalyze the use of CBD as an alternative analgesic to opioids for acute inflammatory pain conditions, which could ultimately help to address the opioid epidemic.”

Epidiolex is a proprietary CBD product derived from cannabis plants manufactured by the British biotechnology firm GW Pharmaceuticals. The FDA approved it in 2018 as a prescription-only treatment for rare seizure disorders. The DEA descheduled it in April 2020.
Full text of the study, “Cannabidiol as an alternative analgesic for acute dental pain,” appears in theJournal of Dental Research.

Meta-Analysis: Cannabis Use Associated With Weight Loss, Lower BMI

Belo Horizonte, Brazil: Subjects who consume cannabis or cannabis-related products in clinical trials typically experience weight loss, according to a meta-analysis published in the International Journal of Obesity.

Brazilian researchers reviewed results from randomized controlled trials involving subjects’ use of cannabis or cannabis-related products.

They reported: “In general, cannabis use reduced weight ... and WC [waist circumference]. When examining subgroups, longer follow-up periods were associated with a more pronounced BMI [body mass index] reduction.”

The study’s authors concluded, “These findings suggest that cannabis and sub-products could be considered adjuncts in obesity treatment by helping to reduce relevant anthropometric measurements.”

A 2022 ecological analysis published in the journal Health Economics reported that the adoption of state-licensed marijuana sales is associated with a decrease in state-level obesity rates.

Case-control studies have consistently reported that those with a history of marijuana use are less likely than abstainers to be obese or to suffer from type 2 diabetes. Studies have also previously linked cannabis use to greater rates of physical activity.

Full text of the study, “Effects of cannabis and sub-products on anthropometric measures: A systematic review and meta-analysis,” appears in the International Journal of Obesity.

Study: Subjects Report That CBD Products Provide Stress Relief

Detroit, MI: CBD oil products provide stress relief, according to data published in the journal Medical Cannabis and Cannabinoids.

Investigators affiliated with Wayne State University’s School of Medicine assessed the short-term use of CBD products in a cohort of 374 participants. Study subjects were instructed to use a 1,000mg hemp-derived CBD isolate product ad libitum for the first half of the trial period. They were then instructed to switch to a 1,000mg broad-spectrum hemp-derived product for the remainder of the study.

Third-party testing confirmed that the isolate product contained CBD and no other cannabinoids. By contrast, the broad-spectrum product contained CBD, CBG, and other cannabinoids, as well as various terpenes.

Researchers reported, “Overall, both products were rated to be highly effective and able to assist with stress management.” However, they added, “Ratings were higher for the broad spectrum as compared to the isolate product, which is consistent with prior data suggesting that cannabinoids can work synergistically to maximize benefits.”

There were no differences in adverse effect ratings for the two products.

The study’s authors concluded: “This quasi-experimental study of nearly 400 adult volunteers compared self-reported effectiveness of two THC-free CBD products -- an isolate and a broad spectrum -- for stress reduction. Overall, participants reported both CBD products to be effective and able to assist with stress management, and that ratings were higher for the broad spectrum as compared to the isolate product. … Together, these data fit with prior studies, suggesting anti-stress effects of CBD. Nonetheless, more controlled studies are needed to explore these effects in both nonclinical and clinical populations.”

Full text of the study, “Effects of two cannabidiol oil products on self-reported stress relief: A quasi-experimental study,” appears in Medical Cannabis and Cannabinoids.

Study: Subjects Report That CBD Products Provide Stress Relief

Detroit, MI: CBD oil products provide stress relief, according to data published in the journal Medical Cannabis and Cannabinoids.

Investigators affiliated with Wayne State University’s School of Medicine assessed the short-term use of CBD products in a cohort of 374 participants. Study subjects were instructed to use a 1,000mg hemp-derived CBD isolate product ad libitum for the first half of the trial period. They were then instructed to switch to a 1,000mg broad-spectrum hemp-derived product for the remainder of the study.

Third-party testing confirmed that the isolate product contained CBD and no other cannabinoids. By contrast, the broad-spectrum product contained CBD, CBG, and other cannabinoids, as well as various terpenes.

Researchers reported, “Overall, both products were rated to be highly effective and able to assist with stress management.” However, they added, “Ratings were higher for the broad spectrum as compared to the isolate product, which is consistent with prior data suggesting that cannabinoids can work synergistically to maximize benefits.”

There were no differences in adverse effect ratings for the two products.

The study’s authors concluded: “This quasi-experimental study of nearly 400 adult volunteers compared self-reported effectiveness of two THC-free CBD products -- an isolate and a broad spectrum -- for stress reduction. Overall, participants reported both CBD products to be effective and able to assist with stress management, and that ratings were higher for the broad spectrum as compared to the isolate product. ... Together, these data fit with prior studies, suggesting anti-stress effects of CBD. Nonetheless, more controlled studies are needed to explore these effects in both nonclinical and clinical populations.”

Full text of the study, “Effects of two cannabidiol oil products on self-reported stress relief: A quasi-experimental study,” appears in Medical Cannabis and Cannabinoids.

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