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Study: Daily Consumers Become Tolerant To Cannabis’ Psychomotor-influencing Effects

Aurora, CO: Daily cannabis consumers exhibit fewer changes in performance than do those who use it less frequently, according to data published in the Journal of Cannabis Research.

A team of investigators affiliated with the University of Colorado and the University of Iowa assessed changes in performance in a cohort of daily versus occasional cannabis consumers. Participants inhaled high-THC flower (15 to 30 percent THC) ad libitum. Researchers compared subjects’ baseline performance to their performance one hour after smoking.

Consistent with prior research, the study’s authors concluded: “In two of the tablet-based tasks, the occasional use group performed slower (reaction time task) or less accurately (memory task) from before to after smoking, as compared to daily use and no-use groups, consistent with daily cannabis use resulting in tolerance to the acute effects of cannabis. In the gap acceptance task, the daily use group took longer to complete the task after smoking cannabis, while at the same time increasing their success ratio.

“Taken together, the findings are consistent with acquired tolerance to certain acute drug effects. The increase in time that the daily use group required to complete the gap acceptance task may nonetheless indicate an acute effect of cannabis among those in the daily use group, who prioritized accuracy over response time. Psychomotor and cognitive assessment batteries, such as the one used in this study, hold promise for providing an objective measure of cannabis impairment.”

NORML opposes the imposition of per se THC thresholds for motorists and alternatively calls for the expanded use of mobile performance technology like DRUID to determine whether someone is under the influence.

Full text of the study, “Effects of acute cannabis inhalation on reaction time, decision-making, and memory using a tablet-based application,” appears in the Journal of Cannabis Research.

Study: Better Sleep Associated With Same-day Cannabis Use In Subjects With Generalized Anxiety

Boulder, CO: Patients with moderate anxiety report experiencing increased sleep quality following their use of cannabis, according to data published in the journal Behavioral Sleep Medicine.

Researchers with the University of Colorado at Boulder assessed the relationship between cannabis use and sleep quality in a cohort of 348 adults with symptoms of generalized anxiety. Study subjects were assigned to consume either cannabis flower or edibles that were either THC dominant, CBD dominant, or contained equal quantities of both cannabinoids. Participants completed daily online surveys for 30 days.

Subjects said that they slept better on those days when they consumed cannabis as compared to days when they did not.

The study’s authors concluded: “We report on 30 days of daily cannabis use and sleep quality data among a community sample with mild-to-moderate anxiety. Our results suggest that cannabis use on a particular day is associated with better perceived sleep quality during the night and that these associations are stronger among those with higher negative affective symptoms and those using CBD dominant edible forms of cannabis.”

The study’s conclusions are consistent with those of a recently published observational trial from the United Kingdom which found that patients with generalized anxiety disorder exhibit sustained symptom relief following their use of cannabis products.

Full text of the study, “Daily associations with cannabis use and sleep quality in anxious cannabis users,” appears in Behavioral Sleep Medicine.

Survey: Cannabis Use Common Among Patients With Cystic Fibrosis

San Francisco, CA: Nearly one-third of patients with cystic fibrosis report having used cannabis within the past year, according to survey data published in the journal Pediatric Pulmonology.

Researchers affiliated with the University of California, San Francisco surveyed 226 cystic fibrosis patients. Respondents lived in the United States and were at least 13 years old.

Twenty-nine percent of those surveyed acknowledged having consumed cannabis in the past year. Twenty-two percent said that they had consumed CBD products.

Consumers of cannabis and CBD products were most likely to report using them to mitigate symptoms of anxiety and depression, to stimulate appetite, and to alleviate arthritic pain.

Among those respondents who had never used either cannabis or CBD products, approximately 50 percent said that they would do so if marijuana was legal.

“There is a great need to expand the current knowledge of and guidance regarding marijuana and CBD use in the CF patient population,” the study’s authors concluded. “Further research is warranted to counsel pwCF (people with cystic fibrosis) accurately, as many report experiencing therapeutic benefits.”

Full text of the study, “Time to be blunt: Substance use in cystic fibrosis,” appears in Pediatric Pulmonology.

Texas: Attorney General Files Suit To Overturn Voter-approved Marijuana Depenalization Measures

Austin, TX: Republican Attorney General Ken Paxton has filed suit against several Texas municipalities for implementing local ballot measures depenalizing marijuana possession offenses.

The suit seeks to nullify laws in the cities of Austin, San Marcos, Killeen, Elgin, and Denton. Voters in all five cities approved local initiatives in 2022 limiting local law enforcement from making arrests or issuing citations for most marijuana-related violations. Local advocates are seeking to place similar measures before voters in Dallas and Lockhart.

The Attorney General argues that localities are forbidden from implementing policies that fail to “fully enforce laws related to drugs.” He said in a press release, “I will not stand idly by as cities run by pro-crime extremists deliberately violate Texas law and promote the use of illicit drugs that harm our communities.”

State law defines marijuana possession as a criminal misdemeanor, punishable by up to 180 days in jail, a $2,000 fine, and a criminal record. According to data compiled by Texas NORML, police made an estimated 219,000 marijuana-related arrests between 2017 and 2021. Ninety-seven percent of those arrested were charged with possession only. Fifty-six percent of those arrested were under 25 years of age.

Additional information is available from Texas NORML.

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Study: Cannabis Not Associated With Higher Risk of Motor Vehicle Accident

Portland, OR: The use of alcohol, but not cannabis, is associated with greater odds of suffering a motor vehicle crash requiring emergency care, according to case-control data published in the journal Accident Analysis and Prevention.

A team of investigators from universities in California, Colorado, and Oregon examined the relationship between cannabis and alcohol use and incidences of motor vehicle collisions (MVC) among patients admitted to emergency departments.

They determined that those who either self-reported or tested positive for the use of alcohol alone possessed a crash risk that was more than twice (OR = 2.50) that of controls (those who tested negative). By contrast, those who either self-reported or tested positive for cannabis possessed a lower risk of accident (OR = .80) than controls.

Those patients who either self-reported or tested positive for the use of both alcohol and cannabis in some instances possessed a higher risk of accident than those who used either substance alone. That finding that is consistent with several prior studies, but others have failed to report this outcome.

Authors concluded: “This was a cross-sectional study of visits to EDs [emergency departments] in Denver, CO, Portland, OR, and Sacramento, CA by drivers who were involved in MVCs and presented with injuries (cases) and non-injured drivers (controls) who presented for medical care. … Our study supported an increased risk for MVC among those with acute alcohol and combined alcohol and cannabis use. Some of our findings suggested an absence of added odds or even reduced odds for MVC among those using cannabis alone prior to driving. … Overall, our study reinforces that in this era of increased liberalization of cannabis, emphasis on actual driving behaviors and clinical signs of intoxication, rather than specific drug-level thresholds, to determine driving under the influence has the strongest rationale.”

NORML has long opposed the imposition of per se THC thresholds for motorists and has alternatively called for the expanded use of mobile performance technology like DRUID to determine whether someone is under the influence.

Full text of the study, “Risk of vehicle collision associated with cannabis and alcohol use among patients presenting for emergency care,” appears in Accident Analysis and Prevention.

Clinical Trial: Cannabis Consumption Associated With Reduced Anxiety

Boulder, CO: The use of state-legal cannabis products is associated with reduced levels of anxiety, according to clinical trial data published in the journal Cannabis and Cannabinoid Research.

Investigators affiliated with the University of Colorado at Boulder assessed subjects’ use of three distinct cannabis chemovars on symptoms of anxiety. Study participants consumed cannabis flower that was either high in THC, high in CBD, or that contained equal levels of THC and CBD ad libitum for four weeks.

Use of all three cannabis varieties was associated with improvements in anxiety symptoms. Those who consumed cannabis that was high in CBD reported the most significant improvements.

The study’s authors concluded: “This quasi-randomized study showed that individuals with generalized anxiety symptoms who used cannabis 3–4 days per week reported reduced anxiety and improved symptoms over the study. The CBD-dominant strain was associated with the greatest reduction in anxiety-related states both acutely and over a period of four weeks. [These] findings extend data on the anxiolytic effects of CBD to naturalistic use and real-world setting and suggest that these effects over a relatively short time frame may translate into longer-term anxiety reductions.”

In January, British scientists writing in the journal Neuropsychopharmacology Reports similarly reported that patients with generalized anxiety disorder exhibit sustained improvements following the use of cannabis products.

Full text of the study, “Acute and extended anxiolytic effects of cannabidiol in cannabis flower: A quasi-experimental ad libitum use study,” appears in Cannabis and Cannabinoid Research.

Poll: Likely Voters Say That Marijuana Should Be Legal for Adults Nationwide

Alexandria, VA: Nearly six in ten likely voters believe that the use of marijuana should be legal in all 50 states, according to nationwide polling data compiled by the Republican-leaning polling firm The Tarrance Group.

Fifty-seven percent of respondents favored a policy of nationwide legalization. Support was strongest among Democrats under the age of 55 (74 percent); however, a majority (55 percent) of Republicans under age 55 also supported legalization.

Regardless of political party, sixty-seven percent of younger voters (ages 18 to 44) backed legalization.

“Majority support exists for marijuana legalization, driven by Democratic and younger voters, as well younger independents and a majority of younger Republicans,” pollsters concluded.

The poll is the latest in a long line of nationwide surveys showing majority support among Americans for ending marijuana criminalization.

The Politics and Advocacy Poll data is available from the Tarrance Group.

Survey: Consumers of CBD Products Frequently Report Using Them in Place of Prescription Medications

Lawrence, KS: Many consumers of CBD products report that they use them as substitutes for prescription medications, according to survey data published in the journal Mental Health Clinician.

Researchers with the University of Kansas School of Pharmacy conducted a nationwide survey of Americans’ use of CBD products. Among those respondents who acknowledged using CBD, nearly one-third reported doing so to mitigate symptoms of anxiety. One-quarter of respondents said they used CBD products for depression and 22 percent said that they used them for pain management.

More than 70 percent of CBD consumers said that it helped alleviate their symptoms and 39 percent acknowledged having “discontinued a prescription medication in favor of CBD.”

Forty-five percent of respondents failed to inform their healthcare providers about their use of CBD products. Prior surveys of healthcare providers report that most providers are either “hesitant” or “uncomfortable” talking about CBD with their patients.

The study’s authors concluded: “[C]onsumers perceived CBD to be safe, effective, and adequately studied for medical purposes. … With the wide availability of CBD, HCPs [health care providers] should be knowledgeable and prepared to provide patients with evidence-based information about CBD.”

Survey data compiled by the National Consumers League reports that more than eight in ten voters desire federal regulatory oversight over the production and marketing of commercially available CBD products, which often contain inaccurate labeling and may contain impurities.

Full text of the study, “Consumer perception, knowledge, and uses of cannabidiol,” appears in Mental Health Clinician.

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CDC Analysis: Youth Cannabis Use Declining, Legalization Likely Responsible

Seattle, WA: Marijuana use by teens fell significantly in King County, Washington (population: 2.3 million) following the state’s adoption of adult-use legalization, according to data provided by the US Centers for Disease Control and Prevention.

Investigators reported that cannabis use fell 60 percent among males and 42 percent among females from 2012 to 2021. (Voters approved a ballot initiative legalizing the adult use market in 2012; retail cannabis sales began in 2014.)

The study’s authors suggested that legalization likely made it more difficult for teens to access cannabis.

“The observed overall decreases in cannabis use among students in grades 8, 10, and 12 might be associated with changes in the availability of cannabis among persons aged >=21 years as well as limited opportunities to engage in use,” they wrote. “The period 2012–2014 includes the legalization of nonmedical cannabis in Washington in 2012. Researchers studying the association of cannabis laws with cannabis use among high school students have observed similar declines in cannabis use after legalization of nonmedical cannabis. The legalization of nonmedical cannabis for adults aged >=21 years in Washington with licensed dispensaries requiring proof of age might have affected availability of cannabis to younger persons as well as their opportunities to engage in its use. This, in turn, might have had an impact on use prevalence.”

The authors’ findings are consistent with those of several other studies documenting declines in young people’s use of cannabis following states’ adoption of adult-use legalization laws.

Full text of the study, “Cannabis use among students in grades 8. 10, and 12, by sex: King County, Washington, 2008-2012,” is available from the Centers for Disease Control and Prevention.

Study: THC Blood Levels Not Correlated With Changes In Driving Performance

Toronto, Canada: The presence of THC in blood is not predictive of detriments in psychomotor performance, according to driving simulator data published in the journal JAMA Network Open.

Researchers affiliated with the University of Toronto assessed subjects’ simulated driving performance at baseline and then again 30 and 180 minutes after smoking cannabis. Participants were between the ages of 65 and 79 years old and smoked cannabis (mean THC potency: 19 percent) ad libitum prior to driving.

Subjects exhibited “small changes in SDLP [weaving]” 30 minutes after cannabis inhalation. Investigators described these changes as less pronounced than those associated with drivers with a BAC below 0.05 percent.

Consistent with the results of prior studies, participants decreased their speed after smoking and were more likely to self-assess their performance as “impaired.” Cannabis use did not impact participants’ reaction times.

Subjects’ simulated driving performance returned to baseline within three hours.

The study’s authors concluded: “The purpose of the present study was to investigate the association between cannabis and driving and blood THC levels in older adults. … There was no correlation between blood THC concentration and SDLP [standard deviation in lateral positioning] or MS [mean speed]. … The lack of correlation between driving and blood THC fits within emerging evidence that there is not a linear relationship between the two.”

That conclusion is consistent with numerous studies reporting that neither the detection of THC nor its metabolites in blood and/or other bodily fluids is predictive of impaired driving performance. As a result, NORML has long opposed the imposition of per se THC limits for motorists and has alternatively called for the expanded use of mobile performance technology like DRUID.

Full text of the study, “Cannabis and driving in older adults,” appears in JAMA Network Open.

Analysis: Cannabis Use In Adolescence Not Independently Linked To Poorer Educational Outcomes

Helsinki, Finland: The use of alcohol, but not cannabis, in adolescence is independently associated with poorer educational attainment, according to longitudinal data published in the journal BMC Public Health.

Finnish investigators assessed the relationship between the use of cannabis and alcohol by adolescents and lifetime educational attainment in a cohort of more than 6,500 subjects.

They reported that the frequent use of alcohol during adolescence was significantly associated with poorer lifetime educational attainment after controlling for confounders. By contrast, early-onset cannabis use was not a statistically significant risk factor after researchers controlled for other variables.

The study’s authors concluded: “In this large birth cohort study with a 17-year follow-up, younger age at first intoxication, higher frequency of alcohol intoxication, and high self-reported alcohol tolerance at age 15/16 years were associated with poorer educational outcomes by the age of 33 years. These adverse associations were evident regardless of a range of potential confounders, such as behavioral/emotional problems at age 7/8 years and parental education level. The association between adolescent lifetime cannabis use and educational attainment in adulthood was no longer statistically significant after adjusting for potential confounders including alcohol use. Our finding that inherent alcohol tolerance in adolescence was associated with subsequent educational attainment has not been previously reported.”

Full text of the study, “Adolescent alcohol and cannabis use in early adulthood educational attainment in the 1986 Finland birth cohort study,” appears in BMC Public Health.

New Jersey: Regulators Finalize Plans For Opening Cannabis Cafes

Trenton, New Jersey: State regulators have signed off on rules governing the operation of cannabis consumption lounges. Regulators are expected to review business applications in the coming months.

Under the plan, dispensary owners would be eligible to open no more than one café. Patrons must be 21 to enter and sales of food or alcohol are prohibited.

Fewer than half of legal cannabis states permit on-site cannabis consumption facilities.

New Jersey legalized the adult-use cannabis market in 2021.

Additional information is available from the New Jersey Cannabis Regulatory Commission.

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