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Clinical Trial: CBD-Infused Gel Relieves Osteoarthritic Hand Pain

Sydney, Australia: The daily application of a transdermal gel containing CBD relieves pain and improves the quality of life of patients with hand osteoarthritis (OA), according to open-label trial data published in the journal Nature: Scientific Reports.

Australian researchers evaluated the self-reported efficacy of transdermal CBD in a cohort of 15 OA patients. Study participants applied CBD-infused gelatin three times a day for four weeks. Self-reported measures were assessed at baseline and throughout the trial via smartphone technology.

CBD application was associated with self-reported improvements in pain, grip strength, fatigue, muscle stiffness, and anxiety.

“Pain, grip strength and QoL [quality of life] measures … were shown to improve over time following transdermal CBD application suggesting feasibility of this intervention in relieving osteoarthritic hand pain,” the study’s authors concluded. “Proof of efficacy, however, requires further confirmation in a placebo-controlled randomized trial.”

The transdermal delivery of CBD has previously been associated with reduced levels of lower back and leg pain in patients with spinal stenosis.

Full text of the study, “An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis,” appears in Nature: Scientific Reports.

Study: History of Cannabis Use Associated With Lower Risk of Prostate Cancer

Farmington, CT: Lifetime cannabis use is associated with lower rates of prostate cancer, according to observational data published in the journal Biomedicines.

Researchers affiliated with the University of Connecticut School of Medicine and the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida assessed the relationship between cannabis consumption and prostate cancer in a nationally representative cohort of 2,503 participants.

Investigators reported that subjects between the ages of 50 and 64 who identified as either current or former cannabis consumers possessed a significantly lower risk of prostate cancer diagnoses. Scientists suggested that this finding provides “biological support for the anti-cancer effects of the constituents of marijuana.” Numerous preclinical trials have documented the ability of cannabinoids to inhibit cancer cell growth.

The study’s authors reported: “In this cross-sectional study of 2503 participants from the USA using the NSDUH [National Survey on Drug Use and Health] from 2002 to 2020, we observed that individuals who were former marijuana users had a significantly lower rate of self-reports of having PC [prostate cancer]. Additionally, the current marijuana users also trended towards lower self-reports of PC. … Specifically, among participants aged greater than 65 years, former marijuana use was linked to reduced self-reports of PC compared to never using.”

They concluded, “Our findings provide corroborative data from a large national, population-based survey to strengthen the existing body of evidence suggesting a potentially protective role of marijuana against the development of PC … [and] our findings can serve as hypothesis-generating for future prospective studies to further evaluate the role of cannabinoids (using medical marijuana) in PC prevention.”

Separate case-control studies have similarly suggested that a history of cannabis use may provide protection against certain types of cancers, including lung cancer and head and neck cancers.

Full text of the study, “Marijuana use may be associated with reduced prevalence of prostate cancer: A National Survey on Drug Use and Health study from the United States of America,” appears in Biomedicines.

Federal: House Committee Approves Amendment Barring Production of Hemp-Derived Intoxicating Products

Washington, DC: Members of the House Committee on Agriculture have approved an amendment to federally criminalize hemp-derived products containing mood-altering cannabinoids.

The amendment revises section 297A of the 2018 Farm Bill, which expanded the definition of hemp to include “any part of the plant, including …. extracts [or] cannabinoids that do not possess greater than 0.3 percent THC on a dry weight basis.” The Farm Bill is up for reauthorization.

The amendment, sponsored by Rep. Mary Miller (R-IL), excludes products from the federal definition of hemp if they contain cannabinoids that “are not capable of being naturally produced” by the hemp plant or if they are the result of a chemical synthesis.

In recent years, unregulated manufacturers have engaged in synthesizing hemp-derived CBD into a variety of novel intoxicating products, including delta-8-THC, HHC, and THC-O. This synthetic conversion process often involves the use of potentially dangerous household products. Lab analyses of unregulated products containing delta-8 and similar compounds have consistently found them to contain lower levels of cannabinoids than what is advertised on the products’ labels. Some products also possess heavy metal contaminants and unlabeled cutting agents. Other novel compounds, like THC-O, have not been tested for safety in human trials.

Studies have reported that consumers are far more likely to seek out and use these products in jurisdictions where cannabis remains criminalized.

In 2021, NORML published a paper cautioning consumers about the unregulated nature of these products.

Further debate on the Farm Bill is anticipated to take place in the coming months.

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Study: Cannabis Use Not Linked To Sedentary Behavior

Toronto, Canada: Young and middle-aged adults who consume cannabis are no less likely than non-users to engage in daily physical activity, according to data published in the journal Cannabis and Cannabinoid Research.

Canadian researchers assessed physical activity in a cohort of 4,666 US adults ages 18 to 59 years old. Subjects wore a portable accelerometer that tracked participant’s daily activity levels. Researchers collected data for a minimum of four days.

Investigators reported that cannabis consumers were slightly more likely than non-users to engage in light physical activity. Researchers reported no differences between the two groups with respect to median daily sedentary time, time spent engaging in vigorous physical exercise, or sleeping.

“Recent cannabis use in young to midlife adults was not associated with accelerometer-measured sedentary or MVPA [moderate-to-vigorous physical activity] time, but it was associated with a marginal increase in LPA [light physical activity] time,” the study’s authors concluded. “Our findings provide evidence against existing concerns that cannabis use independently promotes sedentary behavior and decreases physical activity.

“This study provides useful insight into the association between cannabis use and physical activity, which may help inform clinicians and prescribers with patient counseling, patients and their lifestyle choices, as well as policy makers around public health resource allocations.”

The findings are consistent with those of several prior studies “challenging the stereotype that marijuana … users are less active than their non-using counterparts.” Among those age 60 and older, marijuana use has been associated with increased exercise frequency.

Full text of the study, “Recent cannabis use and accelerometer-measured physical activity and sedentary behavior among young-to-midlife adults: An analysis of the National Health and Nutrition Examination Survey from 2011 to 2014,” appears in Cannabis and Cannabinoid Research.

Canada: No Increase in Hospitalizations Following Adult-Use Legalization

Toronto, Canada: Policies legalizing the use and sale of cannabis products have not led to an increase in marijuana-related hospitalizations, according to data published in the Journal of Addictive Diseases.

Canadian investigators tracked rates of cannabis-related hospitalizations in Alberta in the years prior to and following legalization. Canadian lawmakers legalized the use and sale of cannabis flowers for those ages 18 and older in October 2018. Retailers began engaging in the sales of cannabis concentrates and edible products in 2020.

Researchers identified an increase in hospitalizations among those ages 18 to 24 in the period immediately prior to legalization, but they acknowledged that there were no increases in hospitalizations following legalization among representatives of any age group.

“Legalization was not significantly associated with immediate or ongoing changes in hospitalization rates … for either younger or older adults,” the study’s authors concluded.

Separate Canadian analyses have failed to identify an increase in either traffic-related hospitalizations or ER visits attributable to cannabis-related psychosis following legalization.

Full text of the study, “Cannabis legalization and hospitalizations in Alberta: Interrupted time series analysis by age and sex,” appears in the Journal of Addictive Diseases.

Analysis: Growing Number of Native American Tribes Engaging in Cannabis Sales

Minneapolis, MN: A growing number of Native American tribes are operating marijuana retail businesses, according to data published in the trade publication Marijuana Business Daily.

Nationwide, nearly 60 cannabis retailers are tribally owned – an increase of nearly 25 percent since 2023. Currently, tribes are operating businesses in nine states: California, Michigan, Minnesota, Nevada, New Mexico, New York, North Carolina, South Dakota, and Washington. About three-quarters of tribes engaging in marijuana sales also own and operate casinos.

The greatest number of tribal-owned retailers is in Minnesota. State lawmakers legalized the adult-use marijuana market last year, but regulators have yet to begin licensing retail establishments.

In April, members of the North Carolina Eastern Band of Cherokee Indians opened a medical cannabis dispensary on tribal lands. Tribal leaders are anticipated to approve a separate ordinance to expand sales to adults. Marijuana is not yet legal for either medical use or adult use in the state.

The federal government recognizes 574 Native American tribes, and roughly 350 are in the contiguous 48 states.

The full text of the column, “Tribally owned marijuana store numbers up 25% since 2023,” is available from MJBizDaily.

California: State Assembly Overwhelmingly Approves Bill Permitting Cannabis Retailers To Hold Live Events

Sacramento, CA: Lawmakers in the State Assembly have overwhelmingly voted in favor of legislation, Assembly Bill 1775, permitting cannabis retailers to expand their operations to include serving food and beverages and holding live events.

Lawmakers voted 56 to 6 to advance the bill to the Senate.

The measure authorizes eligible retailers to hold musical and other live performances on their premises. It also permits them to serve non-cannabis infused food and beverages to patrons.

State law already permits authorized facilities to engage in on-site cannabis use.

Lawmakers in both chambers advanced similar legislation last year, but the bill was ultimately vetoed by Democratic Gov. Gavin Newsom.

NORML’s action alert in support of AB 1775 is available in the Take Action Center.

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Analysis: Adult-Use Cannabis Markets Generate Over $20 Billion in State Tax Revenue

Washington, DC: Taxes derived from the licensed sale of state-regulated cannabis products totaled more than $4 billion in 2023, according to an analysis provided by the Marijuana Policy Project.

MPP’s estimates do not include revenues derived from the sale of medical cannabis products or from the collection of state-imposed regulatory fees.

Cannabis sales generated the greatest amount of tax revenue in California (nearly $1.1 billion), followed by Illinois, Washington, and Michigan.

Since 2014, retail sales of adult-use cannabis products have generated more than $20 billion in state tax revenue.

“In many states with legal, adult-use cannabis sales, tax revenues are allocated for social services and programs,” the report’s authors acknowledged. “This includes funding education, school construction, early literacy, public libraries, bullying prevention, behavioral health, alcohol and drug treatment, veterans’ services, conservation, job training, conviction expungement expenses, and reinvestment in communities that have been disproportionately affected by the war on cannabis, among many others.”

Separate economic data published in April reported that the state-licensed cannabis industry added over 23,000 new jobs in 2023 and employs over 440,000 full-time workers.

Full text of the report, “Cannabis Tax Revenue in States that Regulate Cannabis for Adult Use,” is available from MPP.

Study: Patients With Multiple Sclerosis Report Quality of Life Improvements Following Cannabis Therapy

London, United Kingdom: Multiple sclerosis (MS) patients report improvements in their health-related quality of life following the use of medical cannabis preparations, according to observational data published in the journal Multiple Sclerosis and Related Disorders.

British researchers assessed the use of cannabis-based medicinal products (CBMPs) consisting of either flower or oil extracts in 141 MS patients enrolled in the UK Medical Cannabis Registry. (Since 2018, British specialists have been permitted to prescribe cannabis-based medicinal products to patients unresponsive to conventional medications.) Researchers assessed changes in patient-reported outcomes measures at one month, three months, and six months.

Patients reported sustained improvements in their physical and mental health following cannabis therapy. They reported few serious adverse health effects during treatment.

“This case series demonstrates a potential association between [the] initiation of CBMPs and improved patient reported outcomes in sleep, anxiety and general HRQoL [health-related quality of life] measures, over six months,” the study’s authors concluded. “Additional measures for HRQoL, including various physical and mental health subdomains, also exhibit improvements up to six months when compared to baseline.”

A prescription cannabis spray (nabiximols aka Sativex) consisting of specific ratios of THC and CBD is currently available in several countries, including Canada, France, Germany, Spain, and the United Kingdom. The drug is not approved in the United States for treatment of any condition.

Full text of the study, “Clinical outcome analysis of patients with multiple sclerosis – Analysis from the UK Medical Cannabis Registry,” appears in Multiple Sclerosis and Related Disorders.

Minnesota: State Officials Expunge Nearly 60,000 Cannabis Convictions

St. Paul, MN: State officials have reviewed and expunged more than 57,000 low-level marijuana-related convictions, according to data provided this week by the Department of Public Safety, Bureau of Criminal Apprehension.

Legislation passed last year regulating the adult-use cannabis market called for the automatic review and expungement of records for those previously convicted of misdemeanor marijuana-related violations.

“The Bureau of Criminal Apprehension has expunged (also referred to as sealing) 57,780 records in CHS [the Minnesota Criminal History System] almost three months ahead of schedule,” the agency posted Monday on its website.

A separate process will be undertaken to review marijuana-related felony records, some of which may also be eligible for expungement relief.

“These actions together will have a lasting and significant equity impact on communities throughout the state of Minnesota,” James Rowader, Executive Director of the state’s Cannabis Expungement Board, said in a press release.

Twenty-five states have enacted laws facilitating the sealing of eligible marijuana-related convictions. Publicly available data compiled by NORML finds that state courts have sealed the records of an estimated 2.2 million marijuana-related convictions since 2018.

Ohio: Officials Finalize Plans for Retail Marijuana Sales Launch

Columbus, OH: Members of a legislative panel have given final approval to regulations permitting the expedited sale of cannabis products to those age 21 and older.

Under the plan, proposed by the Department of Cannabis Control in April and approved on Monday by the Joint Committee on Agency Rule Review, existing medical dispensaries may apply for dual licensure. (State lawmakers approved medical cannabis access in 2016.) Regulators are anticipated to begin accepting applications on June 7th. Facilities may begin engaging in adult-use cannabis sales immediately following approval.

“The sooner consumers have market access to cannabis products, the more quickly we will begin to see disruptions to the unregulated marketplace,” NORML’s Deputy Director Paul Armentano said. “Retailers provide consumers with the option of obtaining lab-tested products in a safe, regulated environment.”

While state law permits localities to ban the establishment of new adult-use retailers, it does not permit municipalities with existing dispensaries to prohibit them from selling cannabis products to adults.

Adult-use marijuana sales will be subject to a ten percent excise tax in addition to an existing 5.75 percent sales tax. Sales are anticipated to generate between $276.2 million and $403.6 million in annual cannabis tax dollars within five years.

Voters in November approved a citizens-initiated measure (Issue 2) legalizing the possession, home cultivation, and retail sale of cannabis for those age 21 or older. Provisions in the initiative called upon regulators to begin issuing retail licenses by late 2024.

Following the vote, several of the state’s leading Republicans moved to pass legislation gutting many of the initiative’s key provisions. Those efforts stalled after NORML and others generated thousands of communications urging legislators to enact Issue 2 as written.

Twenty-four states have legalized the adult-use marijuana market. Ohio was the 14th to do so by a public vote.

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