#International #Business @WeedConnection

Share This

New WC Franchise in Development @ RRP OG LLC
All Advertising/Media Services Will Be Honored
10-50% DiScOuNt :: Connect / Select You Plan

. . . .

Ask about our current promotion, which is a free listing with purchase of any other service @WeedConnection. Recently started rebuilding our global database and added a new/temp delivery section to our directory. Send us an email to submit any current information. Click here for listing and advertising information. The directory is a huge project that requires maintenance. We still have big plans for future development and production. Join(t) the team as a regional manager, college intern, street team member, or click here for a list of other open positions. Support, subscribe, follow, share, like, and mention growing cannabis business @WeedConnection


#iNTERNATiONAL #Directory

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube @WeedConnection @ Yelp @WeedConnection @ Google+ @WeedConnection @ instaGram

weedconnection.com

#NORML #News @WeedConnection

Share This

Survey: Consumers Frequently Turn to Cannabis To Relieve Pain and Anxiety

Los Angeles, CA: One in four consumers say that their “main goal when using cannabis” is to achieve pain relief, according to survey data provided by the company NuggMD.

The company, which offers physician referrals in several states, surveyed more than 6,500 consumers. Twenty-five percent of respondents said that they use cannabis to mitigate pain. A nearly equal percentage (23 percent) said that they consume cannabis products to relieve anxiety.

Only 13 percent of respondents defined their cannabis use strictly as “recreational.”

The survey’s findings are consistent with those of others reporting that consumers frequently self-medicate with cannabis to assuage pain, anxiety, depression, or problems sleeping.

Data published last year in the journal JAMA Network Open reported that nearly one in four pain patients residing in states where medical cannabis access is legal self-identify as marijuana consumers.

Another study, published in 2023 in the journal Cannabis and Cannabinoid Research, determined that patients who use authorized medical cannabis products experience sustained, “clinically significant improvements in pain interference and tiredness, anxiety, and well-being.”

Study: Cannabis Metabolite at Least Equipotent to THC

Saskatchewan, Canada: The cannabis metabolite 11-hydroxy-THC (11-OH-THC) possesses psychoactive properties that are equal to or greater than those of THC, according to preclinical data published in The Journal of Pharmacology and Experimental Therapeutics.

Canadian investigators compared the activity of THC and 11-hydroxy-THC in mice. They reported that 11-hydroxy-THC “displayed equal or greater activity than the parent compound THC.”

The study’s authors concluded: “The THC metabolite 11-OH-THC likely plays a critical role in the bioactivity of cannabis. … These data provide critical insight … that will inform the interpretation of future cannabinoid research and represent a model for how THC consumption and metabolism may affect cannabis use in humans.”

11-hydroxy-THC is one of two primary metabolites formed following cannabis consumption. It is distinct from 11-nor-9-carboxy-THC, which is not psychoactive and may remain detectable in blood or urine for extended periods. Greater quantities of 11-hydroxy-THC are produced following oral cannabis ingestion than by smoking cannabis flower, which is among the reasons why cannabis-infused edible products are often associated with greater psychoactive effects as compared to herbal cannabis.

Full text of the study, “The intoxication equivalency of 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) relative to delta-9-tetrahydrocannabinol,” appears in The Journal of Pharmacology and Experimental Therapeutics.

Texas: Judge Rejects AG’s Effort To Nullify Austin’s Voter-Approved Marijuana Depenalization Ordinance

Austin, TX: A Travis County district judge has dismissed a lawsuit filed by the state’s Attorney General that sought to overturn the city’s voter-approved marijuana depenalization ordinance.

Austin is one of several Texas cities that has approved a municipal initiative prohibiting local law enforcement from making low-level marijuana-related arrests. Voters in Denton, Elgin, Harker Heights, Killeen, and San Marcos have approved similar measures.

In February, AG Ken Paxton filed suit against the cities of Austin, San Marcos, Killeen, Elgin, and Denton, stating, “I will not stand idly by as cities run by pro-crime extremists deliberately violate Texas law and promote the use of illicit drugs that harm our communities.” Paxton’s office has announced they will appeal the district court’s decision.

The activist group Ground Game Texas seeks to place similar initiatives on the ballot in Dallas and Lockhart this November.

State law defines marijuana possession as a criminal misdemeanor, punishable by up to 180 days in jail, a $2,000 fine, and a criminal record. According to data compiled by Texas NORML, police made an estimated 219,000 marijuana-related arrests between 2017 and 2021. Ninety-seven percent of those arrested were charged with possession only. Fifty-six percent of those arrested were under 25 years of age.

Colorado: Fewer Teens Say It’s “Easy” To Get Marijuana Following Adult-Use Legalization

Denver, CO: The regulation of the adult-use cannabis market in Colorado coincides with declining rates of teen marijuana use, according to data provided by the Department of Public Health.

Data compiled in the latest biannual Healthy Kids Colorado Survey finds that the percentage of high-school students reporting past-month cannabis use fell 37 percent between 2013 and 2023. The percentage of teens who perceive that cannabis is “easy” to obtain cannabis fell by 27 percent during this same period.

Colorado was among the first states to legalize cannabis possession and sales for adults. The state legalized marijuana possession in 2012 and initiated retail sales of cannabis products in 2014.

According to data provided by the Centers for Disease Control and Prevention, the percentage of high schoolers nationwide who use marijuana has fallen an estimated 30 percent over the better part of the past decade. Compliance check data from California, Colorado, Nevada, and other legal marijuana states show that licensed marijuana retailers do not sell products to underage patrons.

In 2021, Dr. Nora Volkow, Director of the US National Institute on Drug Abuse, publicly acknowledged that the enactment of statewide laws regulating the adult-use cannabis market has not led to an increase in the percentage of young people experimenting with the substance.

#NORML #News @WeedConnection

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube

#FollowFriday @Radako_NPO #NQ @WeedConnection

Share This

* Humanitarian & Environmental *
* Causes @Radako_NPO *

#OG @RussellRope #Creator @WeedConnection

 

:: Creator @ WC @ RR Productions ::
:: Follow @RussellRope For Updates ::

#OG @RussellRope #Creator @WeedConnection

:: Join The Revolution ::
:: Read & Take Action ::
:: True OG Stories @ RR ::
:: SUPREME #LegalTrillOG ::

----------------------------------

:: Media Marketing Services @ RRP ::

:: Connect | ADVERTISE | Work | Submit ::

:: Subscribe | Follow | Share | Like | Support ::

:: #FreeTheWeed @WeedConnection ::

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube @WeedConnection @ Yelp @WeedConnection @ Google+ @WeedConnection @ instaGram

weedconnection.com

#International #Business @WeedConnection

Share This

New WC Franchise in Development @ RRP OG LLC
All Advertising/Media Services Will Be Honored
10-50% DiScOuNt :: Connect / Select You Plan

. . . .

Ask about our current promotion, which is a free listing with purchase of any other service @WeedConnection. Recently started rebuilding our global database and added a new/temp delivery section to our directory. Send us an email to submit any current information. Click here for listing and advertising information. The directory is a huge project that requires maintenance. We still have big plans for future development and production. Join(t) the team as a regional manager, college intern, street team member, or click here for a list of other open positions. Support, subscribe, follow, share, like, and mention growing cannabis business @WeedConnection


#iNTERNATiONAL #Directory

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube @WeedConnection @ Yelp @WeedConnection @ Google+ @WeedConnection @ instaGram

weedconnection.com

#NORML #News @WeedConnection

Share This


Survey: Nearly All Patients Report Improvements After Using Medical Cannabis

Sydney, Australia: Adults who consume cannabis to treat a medical condition overwhelmingly say that it improves their symptoms, according to survey data published in the Harm Reduction Journal.

Researchers surveyed over 3,300 Australian adults who self-identified as medical cannabis consumers. Seventy-three percent of respondents said that they primarily consumed prescription cannabis products. (Australian law permits physicians to prescribe cannabis products to patients unresponsive to conventional treatments.) Twenty-seven percent of respondents acknowledged accessing cannabis, primarily from the unregulated market.

Survey participants predominantly consumed either cannabis flower or oral extracts. Patients typically used cannabis to address pain, mood disorders, or sleep disorders.

Ninety-seven percent of those surveyed said that their condition “was a little, much, or very much better since starting medical cannabis,” – a finding that is consistent with the results of prior surveys and observational trials.

Those respondents who used authorized cannabis products were more likely to be aware of the percentage of THC and other cannabinoids in their products. They were also more likely to either vaporize cannabis or consume oral extracts.

The most frequently reported side effects from cannabis were dry mouth, increased appetite, and drowsiness.

The study’s authors reported: “The results … further underline the dramatic recent increase in the proportion of people using legally prescribed rather than illicitly sourced medical cannabis. … Among these dual-users, respondents were far more likely to prefer prescribed medical cannabis for its consistency of dose, ease of getting supplies, effectiveness in treating their condition, better side-effects profile, and reduced risk of legal issues. This highlights the benefits to patients of being able to access medical cannabis of known potency through legal channels rather than having to obtain it from illicit sources.”

They concluded: “Both prescribed and illicit users overwhelmingly endorsed the effectiveness of their medical cannabis in treating their main health condition. … Further high-quality clinical trials and stronger research evidence is required to establish the role of different medical cannabis preparations in treating the wide array of conditions for which medical cannabis is being used.”

Full text of the study, “Medical cannabis use in Australia seven years after legalization: Findings from the online Cannabis as Medicine Survey 2022-2023 (CAMS-22),” appears in the Harm Reduction Journal.

South Africa: Legislation Becomes Law Regulating Personal Cannabis Use

Johannesburg, South Africa: South African President Cyril Ramaphosa has signed legislation (the Cannabis for Private Purposes Act) into law, codifying the personal use of cannabis by adults.

The new law removes cannabis from the federal Drugs and Drug Trafficking Act and recognizes the rights of adults to possess and grow personal use quantities of cannabis in private. It also establishes a process so that those with criminal records for certain marijuana-related offenses can have their convictions expunged.

The law does not establish rules for the commercial production or retail sales of cannabis products. Such activities remain prohibited.

Passage of the law comes years after the nation’s highest court determined that the private use of marijuana by adults is constitutionally protected behavior.

South African lawmakers initially criminalized the use of marijuana in 1908.

In March, German lawmakers passed similar legislation permitting the personal possession and home cultivation of limited amounts of cannabis. Lawmakers in the European nations of Luxembourg and Malta have also recently enacted personal use laws.

The text of the Cannabis for Private Purposes Act is available from the Parliament of the Republic of South Africa.

Mississippi: Governor Signs Legislation Establishing State-Sponsored Cannabis Research Program

Jackson, MS: Republican Gov. Tate Reeves has signed legislation into law establishing a state-sponsored cannabis research program at the University of Mississippi.

Senate Bill 2888 seeks to facilitate and fund medical cannabis research, including “research related to the efficacy and potential health effects of various cannabis delivery methods, including vaporizing, ingesting, topical application, and combustion.”

The University has been licensed by the federal government since 1968 to engage in federally approved cannabis cultivation and research.

MIssissippi lawmakers in 2022 approved a medical cannabis access program for qualified patients. Over 40,000 residents are registered with the program to access cannabis products.

Several states – including California, Colorado, Florida, Kentucky, Pennsylvania, and Utah – have similarly established state-sponsored institutions to study the safety and efficacy of cannabis. Those programs have conducted several FDA-approved clinical trials documenting cannabis’ efficacy in various patient populations.

Preclinical Study: Cannabis Terpenes Produce Potent Analgesic Effects

Tucson, AZ: The administration of select cannabis plant terpenes produces analgesic effects comparable to morphine, according to preclinical data published in The Journal of the Association for the Study of Pain.

Researchers affiliated with the University of Arizona and the National Institutes of Health assessed the pain-relieving effects of various cannabis terpenes – geraniol, linalool, β-pinene, α-humulene, and β-caryophyllene – in a mouse model of chemotherapy-induced peripheral neuropathy.

They reported that each of the selected terpenes “produced roughly equal antinociception to 10 mg/kg of morphine.” The co-administration of low doses of terpenes and morphine produced “enhanced” analgesic effects.

“Together these studies identify cannabis terpenes as potential therapeutics for chronic neuropathic pain,” investigators concluded.

A 2018 clinical trial by researchers at Columbia University previously demonstrated that the co-administration of inhaled cannabis and sub-therapeutic doses of oxycodone produces heightened pain-relieving effects in humans. The results of another clinical trial similarly determined that vaporized cannabis interacts synergistically with opioids and “may allow for opioid treatment at lower doses with fewer side effects.” Observational studies consistently show that patients who consume cannabis reduce or eliminate their use of prescription opioids over time.

Other recent studies have also shown that terpenes can modulate the effects of various cannabinoids. For example, a preclinical study published in April reported that the coadministration of CBD and β-caryophyllene produces enhanced anti-inflammatory effects. Additionally, clinical data published in March determined the co-administration of THC and the terpene D-limonene is associated with reduced feelings of THC-induced anxiety.

The results of a 2023 study found that patients are more likely to report greater symptom relief after consuming cannabis flowers that contain elevated levels of terpenes.

Full text of the study, “Terpenes from cannabis sativa induce antinociception in a mouse model of chronic neuropathic pain via activation of adenosine A2a receptors,” appears in The Journal of the Association for the Study of Pain.

#NORML #News @WeedConnection

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube

#NORML #News @WeedConnection

Share This

Study: Frequent Cannabis Consumers Exhibit No Significant Changes in Driving Performance Following Use of THC-Infused Edibles

Toronto, Canada: Subjects display few changes in simulated driving performance following the ingestion of THC-infused edible products, according to data published in the Journal of Cannabis Research.

Investigators affiliated with the University of Toronto assessed simulated driving behavior in 22 subjects prior to and following the ingestion of THC-infused edibles. Edibles contained, on average, 7.3 mg of THC. Subjects’ driving performance was assessed at two, four, and six hours. Study participants were primarily “frequent users of cannabis for recreational purposes.”

Researchers reported: “Compared to [baseline], cannabis edibles produced a decrease in mean speed 2 hours after consumption. ... No changes in standard deviation of lateral position (SDLP; ‘weaving’), maximum speed, standard deviation of speed or reaction time were found at any time point.” Some participants expressed a lesser willingness to drive following cannabis ingestion.

Researchers theorized that the absence of any significant performance changes may “reflect [subjects’] tolerance to the effects of cannabis” – a phenomenon that has been reported in prior studies. According to one literature review, “Patients who take cannabinoids at a constant dosage over an extensive period of time often develop tolerance to the impairment of psychomotor impairment, so they can drive vehicles safely.”

The study’s authors concluded: “This is the first study of the impact of cannabis edibles on simulated driving. ... Future studies will need to control for age and determine any age-related impacts on the effects of cannabis on driving. This is especially important given that participants over the age of 50 years have been overlooked in studies of the effects of cannabis on driving and related outcomes.”

Full text of the study, “The effect of cannabis edibles on driving and blood THC,” appears in the Journal of Cannabis Research.

Clinical Trial: No Next-Day Impairment Associated With Nighttime Use of Cannabis Oil

Sydney, Australia: Insomnia patients exhibit no next-day impairment following the nighttime use of plant-derived cannabis extracts, according to the results of a randomized, placebo-controlled clinical trial published in the journal Psychopharmacology.

Australian researchers assessed next-day cognitive and psychomotor performance in a cohort of patients diagnosed with insomnia. Subjects in the study consumed either an oral cannabis extract containing 10 mg THC and 200 mg CBD or a placebo.

Investigators identified no differences among those who consumed cannabis or placebo in 27 of 28 performance tests. There were “no impairing effects” on simulated driving performance post-treatment.

The study’s authors concluded: “We found a lack of notable next day impairment to cognitive and psychomotor function and simulated driving performance following evening use of 10 mg oral THC, in combination with 200 mg CBD, in an insomnia population who infrequently use cannabis. ... These findings confirm and extend on prior work by employing a randomized controlled trial design, a patient population that infrequently uses cannabis and who are, on average, older than participants in previous studies, and the use of a regulated product containing a higher ratio of CBD to THC.”

Clinical and observational trial data have reported that the use of cannabis products is associated with improved sleep quality in patients with insomnia.

Full text of the study, “Evaluating possible ‘next day’ impairment in insomnia patients administered an oral medicinal cannabis product by night: A pilot randomized controlled trial,” appears inPsychopharmacology.

Analysis: Proximity to Medical Cannabis Facilities Associated With Perceived Mental Health Improvements in Older Adults

Pittsburgh, PA: Older adults who reside within a 30-minute drive of a licensed medical cannabis dispensary report experiencing fewer days of poor mental health, according to data published by the National Bureau of Economic Research.

Researchers affiliated with the University of Pittsburgh and with John Hopkins University in Baltimore assessed whether proximity to medical cannabis dispensaries was associated with self-reported changes in adult’s mental health.

They reported that local dispensaries were associated with “considerable mental health benefits for older adults.” Specifically, they determined, “[M]edical cannabis availability affected a 3.48 percentage point decrease in persons aged 65 and above reporting having any past-month poor mental health days, a nearly 10 percent decrease from a baseline of 36.3 percent.”

The study’s authors suggested that older adults are likely using cannabis for pain relief and that its analgesic efficacy is also influencing their overall mental health. Data published last year in the Journal of the American Medical Association (JAMA) Network Open reported that nearly one in three patients with chronic pain use cannabis as an analgesic agent and that many of them substitute it in place of opioids.

Researchers did not identify similarly significant effects on mental health among any other subgroups.

Full text of the study, “Medical cannabis availability and mental health: Evidence from New York’s medical cannabis program,” is available online from the National Bureau of Economic Research.

Ohio: Dispensaries May Begin Applying To Serve the Adult-Use Cannabis Market

Columbus, OH: Regulators on Friday will have applications available for those retailers who wish to engage in the licensed sales of cannabis products to adults. Lawmakers last month gave final approval to allow for the expedited sale of adult-use cannabis products by existing medical cannabis dispensaries.

Some retailers with dual licensure are anticipated to begin engaging in adult-use sales before the end of the month. However, most businesses will likely require additional time before they open their doors to the adult-use market.

Dispensaries with dual licensure will need to ensure that they have adequate inventory to serve both medical patients and adults consistently.

Adult-use marijuana sales will be subject to a ten percent excise tax in addition to an existing 5.75 percent sales tax. Sales are anticipated to generate between $276.2 million and $403.6 million in annual cannabis tax dollars within five years.

Voters in November approved a citizens-initiated measure (Issue 2) legalizing the possession, home cultivation, and retail sale of cannabis for those age 21 or older. Provisions in the initiative called upon regulators to begin issuing retail licenses by late 2024.

Following the vote, several of the state’s leading Republicans moved to pass legislation gutting many of the initiative’s key provisions. Those efforts stalled after NORML and other organizations generated thousands of communications urging legislators to enact Issue 2 as written.

Maryland: Frederick County Ceases Pre-Employment Testing for Cannabis

Frederick, MD: City officials in Frederick County, Maryland (population: 287,000) have removed pre-employment drug screening requirements for most public employees.

Under the updated plan, only those seeking jobs in certain “safety-sensitive” positions, such as law enforcement, are required to undergo pre-employment testing for cannabis and other controlled substances. The county employs approximately 3,400 people.

State lawmakers last year approved legislation legalizing the production, sale, and use of cannabis. However, that legislation does not provide explicit workplace protections for those who consume cannabis while away from the job.

Separate legislation introduced this year limiting employers’ abilities to sanction workers who test positive for their past use of marijuana died in committee.

Frederick County Executive Jessica Fitzwater said that pre-employment drug testing requirements “created an unnecessary barrier to employment.”

Numerous other municipalities and counties nationwide -- including Atlanta, Cleveland, the District of Columbia, Philadelphia, and St. Louis – have similarly ended pre-employment marijuana screening for most public employees. Lawmakers in Michigan, Nevada, and Washington have passed legislation halting pre-employment marijuana testing statewide. Several other states -- including California, Connecticut, Minnesota, Montana, New Jersey, New York, and Rhode Island — have enacted broader workplace protections limiting employers’ ability to either test or sanction employees for the use of cannabis use while off the job.

#NORML #News @WeedConnection

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube

#FollowFriday @TheTrueOGReport #ComingSoon @WeedConnection

Share This
* New Show NQ @TheTrueOGReport *

* READ & Click & READ & Click *

:: Creator @ WC @ RR Productions ::
:: Follow @RussellRope For Updates ::

#OG @RussellRope #Creator @WeedConnection

:: Join The Revolution ::
:: Read & Take Action ::
:: True OG Stories @ RR ::
:: SUPREME #LegalTrillOG ::

----------------------------------

:: Media Marketing Services @ RRP ::

:: Connect | ADVERTISE | Work | Submit ::

:: Subscribe | Follow | Share | Like | Support ::

:: #FreeTheWeed @WeedConnection ::

WeedConnection @ Twitter @WeedConnection @ Facebook @WeedConnection @ LinkedIn @WeedConnection @ Foursquare @WeedConnection @ Spotify @WeedConnection @ YouTube @WeedConnection @ Yelp @WeedConnection @ Google+ @WeedConnection @ instaGram

weedconnection.com